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Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer.

Author: DingQichen, HuangWeidan, LiMaolan, LiuYingbin, LuJianhua, MuJiasheng, TanZhujun, WuXiangsong, XiaoJing, XuHaineng, YangYu, ZhangLin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the anticancer effects of thioridazine, an antipsychotic drug, in gastric cancer cell lines. Thioridazine induced apoptosis in gastric cancer cells in vitro and inhibited tumor growth in vivo, suggesting its potential as a drug for gastric cancer therapy.
Paper Details　
Original Abstract of the Article :
Thioridazine, an antipsychotic drug, has been reported to induce apoptosis in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs). However, whether it elicits anticancer effects in gastric cancer has never been reported. In the present study, we examined the ability...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.3892/or.2014.3068

データ提供：米国国立医学図書館（NLM）

Thioridazine: A Potential New Weapon in the Fight Against Gastric Cancer

The quest for effective [gastric cancer] treatments continues to be a top priority in the field of [oncology]. This research investigates the anticancer properties of [thioridazine], a drug primarily used to treat [mental health conditions].

The authors conducted [in vitro and in vivo studies] to explore the effects of thioridazine on [gastric cancer cells]. They found that thioridazine exhibited significant anticancer activity, inducing cell death and inhibiting tumor growth.

New Possibilities for Cancer Treatment

The study suggests that thioridazine may hold potential as a [new treatment] for gastric cancer. Its ability to induce [apoptosis] in cancer cells and inhibit tumor growth is a promising development.

Hope for Gastric Cancer Patients: A Cautious Optimism

While these findings are encouraging, further research is needed to determine the safety and effectiveness of thioridazine in treating gastric cancer in humans. However, this study offers hope for patients seeking alternative therapies.

Dr. Camel's Conclusion

As a researcher, I find it fascinating that a drug traditionally used for mental health conditions could exhibit potent anticancer activity. This study showcases the unexpected discoveries that can emerge from interdisciplinary research. It's a reminder that we should always be open to exploring new possibilities in the fight against cancer.

Date :
  1. Date Completed 2015-01-12
  2. Date Revised 2014-04-04
Further Info :

Pubmed ID

24604290

DOI: Digital Object Identifier

10.3892/or.2014.3068

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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