Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity.

Author: BarjaGustavo, CrucesJulia, De la FuenteMonica, GomezJose, GómezAlexia, Lopez-TorresMónica, MateIanire, NaudiAlba, PamplonaReinald, Portero-OtinManuel, Sánchez-RomanInes

Paper Details 
Original Abstract of the Article :
The membrane fatty acid unsaturation hypothesis of aging and longevity is experimentally tested for the first time in mammals. Lifelong treatment of mice with the β1-blocker atenolol increased the amount of the extracellular-signal-regulated kinase signaling protein and successfully decreased one of...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326892/

データ提供:米国国立医学図書館(NLM)

Atenolol and Membrane Fatty Acid Unsaturation: A Study of Aging and Longevity

The world of [aging and longevity] is a vast and mysterious desert, where the secrets to a long and healthy life are often hidden beneath layers of time and complexity. This research explores the impact of atenolol, a beta-blocker commonly used to treat high blood pressure, on membrane fatty acid unsaturation, a key feature of cellular membranes that plays a role in aging and longevity. The study investigates the effects of lifelong atenolol treatment on mice, examining the changes in their heart and skeletal muscle mitochondria, as well as their overall health and lifespan.

The study, like a desert explorer unearthing a hidden oasis, reveals that atenolol significantly reduces membrane fatty acid unsaturation in heart and skeletal muscle mitochondria. This finding is like discovering a hidden spring that could potentially slow down the aging process. The research also notes that atenolol improves various immune and behavioral functions in mice, suggesting a broader impact on overall health.

Atenolol: A Potential Elixir for Longevity?

While the study does not demonstrate a direct increase in lifespan, it provides compelling evidence that atenolol can positively impact cellular aging processes and improve overall health in mice. This finding is like uncovering a hidden path in the desert that could lead to a longer and healthier life.

The Promise of Cellular Renewal

This research, like a desert oasis offering hope in the face of adversity, suggests that targeting cellular aging processes, like membrane fatty acid unsaturation, could potentially contribute to a longer and healthier life. While further research is needed to confirm these findings in humans, this study offers a glimmer of hope in the quest to combat aging and extend lifespan.

Dr.Camel's Conclusion

The desert of aging is vast and mysterious, with countless secrets waiting to be uncovered. This research, like a journey through a shifting landscape, provides valuable insights into the potential impact of atenolol on the aging process. It's a reminder that the quest for longevity is a continuous adventure, fueled by scientific discovery and a desire to unravel the mysteries of life's journey.

Date :
  1. Date Completed 2015-03-30
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

24612513

DOI: Digital Object Identifier

PMC4326892

Related Literature

SNS
PICO Info
in preparation
Languages

English

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