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Endocrine side-effects of anti-cancer drugs: the impact of retinoids on the thyroid axis.

Author: DalleStéphane, Graeppi-DulacJulia, OrgiazziJacques, Perier-MuzetMarie, Vlaeminck-GuillemVirginie

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Bexarotene, a treatment for late stage cutaneous T-cell lymphomas, can cause hypothyroidism by suppressing TSH production. This review examines the mechanisms by which rexinoids repress TSHB, αTSH, and TRH genes.
Paper Details　
Original Abstract of the Article :
Bexarotene (Targretin), approved since 1999 as a second-line treatment for late stage cutaneous T-cell lymphomas, has been shown to induce significant hypothyroidism through TSH suppression. This review revisits, through a case report, mechanisms by which rexinoids repress the expression of TSHB gen...See full text at original site
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引用元：
https://doi.org/10.1530/EJE-13-0920

データ提供：米国国立医学図書館（NLM）

Retinoids and the Thyroid: Navigating the Desert of Hormonal Interactions

Imagine a camel caravan traversing a vast desert, its journey influenced by the interplay of different hormones. This research explores the complex relationship between retinoids, a class of medications used to treat certain cancers, and the thyroid axis, a crucial regulatory system in the body.

The study examines the potential side effects of retinoids on the thyroid, specifically their ability to suppress TSH production. TSH, like a guidepost in the desert, plays a vital role in regulating thyroid hormone levels.

The Impact of Retinoids: Navigating the Desert of Side Effects

The findings suggest that retinoids can have a significant impact on the thyroid axis, potentially leading to hypothyroidism. It's like a camel caravan encountering a sandstorm that disrupts its usual route, causing unexpected delays and challenges.

Understanding Hormonal Interactions

This research highlights the importance of understanding the potential interactions between different medications and hormonal systems. It's like navigating a vast desert where the interplay of different elements can lead to unexpected outcomes.

Dr.Camel's Conclusion

Retinoids, like a camel caravan's supplies, can have unexpected interactions with the thyroid axis. This study provides valuable insights into these complex hormonal interactions, reminding us of the need for careful monitoring and management of medications that can affect the delicate balance of the body's systems.

Date :
  1. Date Completed 2014-07-02
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

24616413

DOI: Digital Object Identifier

10.1530/EJE-13-0920

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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