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Changes in mipomersen dosing regimen provide similar exposure with improved tolerability in randomized placebo-controlled study of healthy volunteers.

Author: BakerBrenda F, FlaimJoann D, GrundyJohn S, KasteleinJohn J P, McGowanMary P

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Mipomersen (200mg once weekly), an apolipoprotein B synthesis inhibitor, has a similar drug exposure and overall safety profile at lower doses (30mg once daily, 70mg 3 times weekly).
Paper Details　
Original Abstract of the Article :
BACKGROUND: Mipomersen, an apolipoprotein B synthesis inhibitor, demonstrated significant reductions in low-density lipoprotein (LDL) cholesterol, non-high density lipoprotein cholesterol, and apolipoprotein B in 4 phase 3 studies at the FDA-approved subcutaneous dose of 200 mg once weekly. METHODS...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187476/

データ提供：米国国立医学図書館（NLM）

Mipomersen Dosing Regimen: Finding the Right Oasis in the Desert of Cholesterol

The fight against high cholesterol is an ongoing journey, with researchers constantly seeking better ways to manage this common health concern. This research focuses on mipomersen, a medication that inhibits the production of apolipoprotein B, a key protein involved in cholesterol transport. The study aims to optimize the dosing regimen of mipomersen, exploring various approaches to achieve similar levels of effectiveness while minimizing potential side effects. They discovered that different dosing regimens resulted in comparable drug exposure, suggesting flexibility in treatment without compromising efficacy. This is like finding a different oasis in the vast desert of cholesterol management, offering patients more personalized options.

Navigating the Desert of Cholesterol: Finding the Right Oasis

The findings highlight the potential for flexibility in mipomersen dosing regimens. The study reveals that similar drug exposure can be achieved with different approaches, offering patients more individualized treatment options. This flexibility could lead to improved tolerability and adherence to treatment, ultimately contributing to better cholesterol management.

The Importance of Personalized Medicine

This research underscores the importance of personalized medicine, tailoring treatment approaches to individual needs. The ability to adjust mipomersen dosing based on patient factors could lead to more effective and well-tolerated treatment, helping patients navigate the desert of cholesterol management with greater ease.

Dr.Camel's Conclusion

This study, like a well-mapped desert route, guides us towards personalized approaches to cholesterol management. The flexibility in mipomersen dosing offers patients a new oasis, allowing for tailored treatments that can improve both efficacy and tolerability.

Date :
  1. Date Completed 2014-11-18
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

24627419

DOI: Digital Object Identifier

PMC4187476

Related Literature

Article Analysis
・Effects of mipomersen injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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