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Human leukocyte antigen (HLA) pharmacogenomic tests: potential and pitfalls.

Author: DalyAnn K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Certain genetic variations, known as HLA alleles, can increase the risk of developing serious side effects from various medications. For example, people with the HLA-B*57:01 allele have a 100% chance of developing a hypersensitivity reaction to the HIV drug abacavir. This information is used to advise patients and healthcare professionals on safe medication use.
Paper Details　
Original Abstract of the Article :
Adverse drug reactions involving a range of prescribed drugs and affecting the skin, liver and other organs show strong associations with particular HLA alleles. For some reactions, HLA typing prior to prescription, so that those positive for the risk allele are not given the drug associated with th...See full text at original site
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引用元：
https://doi.org/10.2174/138920021502140327180733

データ提供：米国国立医学図書館（NLM）

The Power of HLA Typing: A Personalized Approach to Drug Safety

The realm of [pharmacogenomics] is a rapidly evolving field, and this study explores the potential of [human leukocyte antigen (HLA) typing] in improving drug safety. The authors delve into the complex interplay between HLA alleles and adverse drug reactions, highlighting the potential benefits of pre-prescription HLA typing to identify individuals at risk of developing these reactions.

A Personalized Approach to Drug Safety: The Promise of HLA Typing

This study demonstrates the potential of HLA typing to enhance drug safety, particularly for drugs associated with specific HLA-related adverse reactions. The authors showcase the successful implementation of HLA typing for abacavir, a drug for HIV infection, significantly reducing the risk of hypersensitivity reactions. This research highlights the importance of personalized medicine in optimizing drug therapy and minimizing adverse events.

Navigating the Complexities of HLA Typing: A Balancing Act of Precision and Accessibility

This study underscores the importance of balancing the precision of HLA typing with its accessibility and cost-effectiveness. While HLA typing has shown significant promise for certain drugs, the authors acknowledge the need for further research to refine its application for other medications. This research emphasizes the ongoing need for advancements in HLA typing technology and broader implementation to improve drug safety and patient outcomes.

Dr. Camel's Conclusion

This study highlights the potential of HLA typing to revolutionize drug safety, offering a personalized approach to minimizing adverse events. The research underscores the importance of ongoing research and development in this field, aiming to optimize HLA typing technology and ensure its accessibility for wider application in clinical practice.

Date :
  1. Date Completed 2014-11-24
  2. Date Revised 2019-10-27
Further Info :

Pubmed ID

24694233

DOI: Digital Object Identifier

10.2174/138920021502140327180733

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