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Myocardial and anti-inflammatory effects of chronic bosentan therapy in monocrotaline-induced pulmonary hypertension.

Author: FontouraDulce, LeiteSara, Leite-MoreiraAdelino F, LourençoAndré P, Mendes-FerreiraPedro, Oliveira-PintoJosé, Tavares-SilvaMarta, Vasques-NóvoaFrancisco

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Endothelin-1 antagonists are used to treat pulmonary hypertension, but their effects on the heart and overall body are not fully understood. This study investigated their effects in a rat model of pulmonary hypertension.
Paper Details　
Original Abstract of the Article :
Endothelin-1 antagonists are increasingly used in the treatment of pulmonary hypertension despite the lack of knowledge of their myocardial and systemic effects. We assessed the right ventricular myocardial and systemic effects of endothelin-1 antagonists in monocrotaline-induced pulmonary hypertens...See full text at original site
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引用元：
https://doi.org/10.1016/j.repc.2013.09.016

データ提供：米国国立医学図書館（NLM）

Bosentan: Exploring a Desert Oasis of Potential

The treatment of pulmonary hypertension is an ongoing pursuit, like a quest for a hidden oasis in the vast and unforgiving desert. This research delves into the [myocardial and anti-inflammatory effects] of [chronic bosentan therapy] in [monocrotaline-induced pulmonary hypertension]. It's like studying the impact of a particular plant on the desert ecosystem, seeking to understand its beneficial or detrimental effects.

A Hidden Oasis of Benefits: Unveiling the Potential of Bosentan

This research investigates the potential benefits of [bosentan] for managing [pulmonary hypertension]. The authors examine the impact of [chronic bosentan therapy] on [right ventricular myocardial function] and [systemic inflammation]. It's like discovering a hidden spring in the desert that offers a unique and refreshing source of relief. This research suggests that [bosentan] may offer a promising treatment option for [pulmonary hypertension] by improving [cardiac function] and reducing [inflammation].

A Desert Oasis of Hope: Finding Solutions for Pulmonary Hypertension

This research encourages further exploration of [bosentan] as a treatment option for [pulmonary hypertension]. It's like finding a beacon of light in the desert, guiding us towards a healthier future. This research highlights the importance of understanding the [myocardial and systemic effects] of medications used to treat this complex condition. It encourages a holistic approach to treatment, considering the impact on both the heart and the overall body.

Dr.Camel's Conclusion

The desert of [pulmonary hypertension] research continues to expand. This research offers a glimpse into the potential benefits of [bosentan], suggesting it could be a valuable tool in managing this challenging condition. It's like finding a hidden oasis in the desert, offering a source of hope and resilience for those affected by this disease.

Date :
  1. Date Completed 2015-11-30
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

24780128

DOI: Digital Object Identifier

10.1016/j.repc.2013.09.016

Related Literature

Article Analysis
・Effects of bosentan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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