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Tadalafil enhances the neuroprotective effects of ischemic postconditioning in mice, probably in a nitric oxide associated manner.

Author: GulatiPuja, SinghNirmal

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tadalafil, a drug for erectile dysfunction, was found to mimic the neuroprotective effects of ischemic postconditioning (iPoCo) in a mouse model of stroke, potentially by increasing nitric oxide production.
Paper Details　
Original Abstract of the Article :
This study investigates the modulatory effect of tadalafil, a selective phosphodiesterase (PDE-5) inhibitor, on the neuroprotective effects of ischemic postconditioning (iPoCo) in mice. Bilateral carotid artery occlusion (BCAO) for 12 min followed by reperfusion for 24 h was employed to produce isch...See full text at original site
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引用元：
https://doi.org/10.1139/cjpp-2013-0428

データ提供：米国国立医学図書館（NLM）

Tadalafil Enhances Neuroprotective Effects of Ischemic Postconditioning in Mice: A Role for Nitric Oxide

The study explores the interaction between tadalafil, a phosphodiesterase type 5 (PDE-5) inhibitor, and ischemic postconditioning (iPoCo) in protecting against cerebral injury. The authors investigated the effects of tadalafil on the neuroprotective effects of iPoCo in a mouse model of ischemic stroke. They found that tadalafil enhanced the neuroprotective effects of iPoCo, possibly through a nitric oxide (NO)-dependent pathway. The study suggests that PDE-5 could be a potential target for improving the neuroprotective effects of iPoCo.

Tadalafil: A Potential Booster for Neuroprotection

The study's findings suggest that tadalafil, a drug commonly used to treat erectile dysfunction, may also offer neuroprotective benefits. The enhanced neuroprotective effects of iPoCo in the presence of tadalafil suggest that combining these interventions could improve outcomes in patients experiencing ischemic stroke.

Navigating the Desert of Stroke Recovery: Exploring New Avenues

As Dr. Camel, I am always excited to see research exploring novel strategies for treating stroke. The study's findings offer a promising avenue for improving neuroprotection and enhancing recovery after stroke.

Dr. Camel's Conclusion

This study demonstrates the potential of tadalafil to enhance the neuroprotective effects of ischemic postconditioning in a mouse model of stroke. It suggests that PDE-5 could be a promising target for developing new therapies to improve neurological outcomes after stroke.

Date :
  1. Date Completed 2015-04-21
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

24784472

DOI: Digital Object Identifier

10.1139/cjpp-2013-0428

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Languages

English

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