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Evaluating the promiscuous nature of tyrosine kinase inhibitors assessed in A431 epidermoid carcinoma cells by both chemical- and phosphoproteomics.

Author: BennettKeiryn L, GiansantiPiero, GridlingManuela, HeckAlbert J R, HuberKilian V M, PreisingerChristian, Superti-FurgaGiulio

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the direct targets and downstream signaling effects of four tyrosine kinase inhibitors (imatinib, dasatinib, bosutinib, and nilotinib) in epidermoid carcinoma cells using a multilevel quantitative mass spectrometry-based proteomic strategy. The researchers identified over 25 tyrosine kinases with affinity to the drugs and found that imatinib and nilotinib displayed higher specificity compared to dasatinib and bosutinib.
Paper Details　
Original Abstract of the Article :
Deregulation of protein tyrosine kinase signaling has been linked to many diseases, most notably cancer. As a consequence, small molecule inhibitors of protein tyrosine kinases may provide powerful strategies for treatment. Following the successful introduction of imatinib in the treatment of chroni...See full text at original site
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引用元：
https://doi.org/10.1021/cb500116c

データ提供：米国国立医学図書館（NLM）

Deciphering the Complex World of Tyrosine Kinase Inhibitors

The field of cancer research is a vast and complex desert, with researchers constantly seeking new ways to target and eradicate cancer cells. This study examines the promiscuous nature of tyrosine kinase inhibitors (TKIs), drugs that block the activity of tyrosine kinases, proteins that play a key role in cell growth and survival. It's like navigating a labyrinth of pathways, each potentially leading to a different outcome.

Understanding TKI's Promiscuity

The researchers, like skilled cartographers, mapped out the intricate network of interactions between TKIs and their targets. They found that some TKIs exhibit a broader range of targets than others, leading to potential side effects. This discovery underscores the importance of understanding the full spectrum of a drug's effects.

Implications for Cancer Treatment

The insights gained from this study are invaluable for optimizing cancer treatment strategies. By understanding the complex interplay between TKIs and their targets, researchers can develop more precise and effective treatments that minimize side effects and maximize therapeutic benefit.

Dr. Camel's Conclusion

This study is a reminder that the journey towards conquering cancer is fraught with challenges. By carefully navigating the complexities of drug interactions, we can unlock new pathways towards more effective and personalized cancer therapies.

Date :
  1. Date Completed 2015-02-26
  2. Date Revised 2014-07-18
Further Info :

Pubmed ID

24804581

DOI: Digital Object Identifier

10.1021/cb500116c

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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