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In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study.

Author: BuckleyBrendan M, DevlinJames J, FordIan, JohnsonPaul C D, JukemaJ Wouter, KearneyPatricia M, PostmusIris, SacksFrank M, SattarNaveed, ShiffmanDov, SlagboomP Eline, StottDavid J, TrompetStella, WestendorpRudi G J, de CraenAnton J M

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Statin therapy is widely used for preventing and treating cardiovascular events, but individual responses to statin treatment vary in terms of LDL cholesterol reduction and clinical outcomes. Genetic factors may play a significant role in these individual responses.
Paper Details　
Original Abstract of the Article :
Statin therapy is widely used in the prevention and treatment of cardiovascular events and is associated with significant risk reductions. However, there is considerable variation in response to statin therapy both in terms of LDL cholesterol reduction and clinical outcomes. It has been hypothesized...See full text at original site
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引用元：
https://doi.org/10.1016/j.atherosclerosis.2014.04.009

データ提供：米国国立医学図書館（NLM）

Unraveling the Genetic Secrets of Statin Response

The field of [pharmacogenetics] is a fascinating frontier, exploring the intricate relationship between genetics and drug response. This study delves into the individual variation in response to [statin therapy] by investigating potential [genetic determinants]. The authors hypothesize that [genetic variation] plays a significant role in influencing both [LDL cholesterol reduction] and [clinical outcomes]. This study provides a foundation for personalized statin therapy, tailoring treatments to individual genetic profiles.

Genetics: The Key to Personalized Statin Therapy

This research highlights the vital role of genetics in individualizing statin therapy. By understanding how genetic factors influence drug response, healthcare providers can optimize treatment regimens for each patient, maximizing benefits and minimizing risks. It's like having a map of the desert (genetic profile) that guides you to the best path (personalized statin therapy).

A Personalized Approach to Statin Treatment

This research emphasizes the need for a personalized approach to statin treatment. By taking into account individual genetic predispositions, healthcare providers can tailor statin therapy to optimize effectiveness and minimize potential side effects. It's like choosing the right camel for a desert journey: a camel that's well-suited to the specific terrain will ensure a smoother and more successful expedition.

Dr.Camel's Conclusion

This research underscores the exciting potential of pharmacogenetics in revolutionizing drug treatment, particularly in the realm of statin therapy. By deciphering the genetic code that influences drug response, researchers pave the way for a more personalized and effective approach to healthcare. Just as a camel adapts its gait to the changing sands of the desert, we must adapt our medical practices to the unique needs of each individual.

Date :
  1. Date Completed 2016-05-10
  2. Date Revised 2014-06-09
Further Info :

Pubmed ID

24816038

DOI: Digital Object Identifier

10.1016/j.atherosclerosis.2014.04.009

Related Literature

Article Analysis
・Effective treatment of statins
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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