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Pasireotide for postoperative pancreatic fistula.

Author: AllenPeter J, BrennanMurray F, BucknorAdjoa A, CarlucciKate E, D'AngelicaMichael I, DeMatteoRonald P, FongYuman, GönenMithat, JarnaginWilliam R, KinghamT Peter, PappasMarisa M, RobinsonLindsay M

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Pasireotide is a somatostatin analogue that can reduce pancreatic exocrine secretions. This study suggests that it may prevent postoperative pancreatic fistula, a serious complication after pancreatic surgery.
Paper Details　
Original Abstract of the Article :
Postoperative pancreatic fistula is a major contributor to complications and death associated with pancreatic resection. Pasireotide, a somatostatin analogue that has a longer half-life than octreotide and a broader binding profile, decreases pancreatic exocrine secretions and may prevent postoperat...See full text at original site
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引用元：
https://doi.org/10.1056/NEJMoa1313688

データ提供：米国国立医学図書館（NLM）

Pasireotide for Postoperative Pancreatic Fistula: A New Hope

Postoperative pancreatic fistula, a leakage from the pancreas following surgery, is a serious complication that can lead to significant complications and even death. Imagine a camel that has been injured during a long and arduous journey across the desert, experiencing a debilitating leak from its internal organs. This is a dire situation that requires prompt medical attention.

This study investigates the potential benefits of pasireotide, a somatostatin analogue, in preventing postoperative pancreatic fistula. The researchers are seeking a way to help these injured camels recover and avoid further complications. Pasireotide, with its longer half-life and broader binding profile, may be a promising tool for reducing pancreatic secretions and preventing leakage.

Pasireotide: A Potential Oasis in the Desert of Pancreatic Fistula

This study highlights the potential benefits of pasireotide in preventing postoperative pancreatic fistula. The findings offer hope for patients facing this serious complication, potentially improving their recovery and reducing the risk of further complications.

Navigating the Desert of Pancreatic Complications: Finding a Safe Passage

Postoperative pancreatic fistula is a significant complication that can lead to prolonged recovery and even death. This study underscores the importance of research into effective treatment and prevention strategies for this condition. It's essential to consult with a healthcare professional to discuss potential risks and benefits of various treatment options. Just like a camel needs to choose its path carefully to navigate a desert, patients with pancreatic fistula need to be guided by skilled and experienced medical professionals.

Dr. Camel's Conclusion

This study provides a ray of hope for patients at risk of postoperative pancreatic fistula. Pasireotide, with its unique properties, may be a valuable tool in preventing this serious complication. Remember, just as a camel needs to be vigilant and cautious in the desert, it's important to seek professional guidance and follow recommended treatment plans to minimize the risk of complications after surgery.
Date :
  1. Date Completed 2014-05-29
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

24849084

DOI: Digital Object Identifier

10.1056/NEJMoa1313688

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Article Analysis
・Effects of pasireotide injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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