Paper Details

  1. Home
  2. Paper Details

Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice.

Author: GuanXu, HeTing, HuangYunjian, NieLing, SunLei, WangJunping, WangSong, XiaoTangli, YangKe, ZhangJingbo, ZhaoJinghong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Rapamycin is a drug that can reduce kidney damage in diabetic mice by increasing autophagy (a process that helps cells to clean up waste) and inhibiting apoptosis (cell death).
Paper Details　
Original Abstract of the Article :
The aim was to explore the effects of rapamycin on autophagy and injury of podocytes in streptozocin (STZ)-induced type 1 diabetic mice, and its role in delaying progression of diabetic nephropathy. In this study, male Balb/c mice were divided into three groups: control (n = 12), STZ-induced diabeti...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s11010-014-2090-7

データ提供：米国国立医学図書館（NLM）

Rapamycin: A Potential Oasis in the Desert of Diabetic Nephropathy

Diabetic nephropathy, a serious complication of diabetes, can cause damage to the kidneys. This study investigates the effects of rapamycin, an immunosuppressant drug, on kidney injury in diabetic mice. The researchers found that rapamycin promoted autophagy, a process by which cells recycle their components, in podocytes, specialized cells in the kidneys. This increased autophagy activity helped to reduce kidney damage and improve kidney function in diabetic mice.

Rapamycin's Potential to Combat Kidney Damage

This study suggests that rapamycin could be a promising treatment for diabetic nephropathy. The drug's ability to promote autophagy in podocytes appears to protect against kidney damage. Further research is needed to confirm these findings in humans.

Navigating the Desert of Kidney Disease

Diabetic nephropathy is a serious desert of kidney disease, but this study offers a glimmer of hope. Rapamycin's potential to promote autophagy and protect against kidney damage is encouraging. More research is needed, but this study provides a promising avenue for developing new therapies to combat this debilitating condition.

Dr.Camel's Conclusion

The desert of diabetic nephropathy is a challenging landscape for patients and researchers, but this study suggests that rapamycin may be a valuable oasis in this journey. Its ability to promote autophagy and protect against kidney damage offers hope for new treatment strategies.

Date :
  1. Date Completed 2015-10-26
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

24850187

DOI: Digital Object Identifier

10.1007/s11010-014-2090-7

Related Literature

Article Analysis
・Effects of sirolimus (with albumin) injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.