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Effect of TNF-alpha inhibitor treatment on bone mineral density in patients with ankylosing spondylitis: a systematic review and meta-analysis.

Author: Al GhanimNayef, CheungAngela M, HaroonNisha Nigil, InmanRobert D, SriganthanJeevitha

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study examines the effect of TNF inhibitors, a type of medication used to treat ankylosing spondylitis (AS), on bone density in the spine and hips of people with AS. AS is associated with an increased risk of osteoporosis and fractures, and the study aims to understand how TNF inhibitors might impact bone health.
Paper Details　
Original Abstract of the Article :
Ankylosing spondylitis (AS) is a chronic inflammatory disease associated with an increased risk of osteoporosis and fractures. TNF inhibitors have been used to treat AS, but their effect on bone is unclear. Thus, we conducted a meta-analysis to study the effect of TNF inhibitors on spine and hip BMD...See full text at original site
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引用元：
https://doi.org/10.1016/j.semarthrit.2014.05.008

データ提供：米国国立医学図書館（NLM）

TNF-alpha Inhibitors and Ankylosing Spondylitis: A Balancing Act for Bone Health

Ankylosing spondylitis (AS) is a chronic inflammatory disease that can affect the spine, causing pain and stiffness, much like a desert sandstorm relentlessly pushing against a traveler. This study focuses on the impact of TNF-alpha inhibitors, a class of medications used to treat AS, on bone mineral density. The researchers, like skilled architects, analyzed a large dataset of patients with AS, seeking to understand the interplay between TNF-alpha inhibitors and bone health.

TNF-alpha Inhibitors and Bone Mineral Density: A Complex Equation

The study, like a meticulously crafted sandcastle, reveals a complex relationship between TNF-alpha inhibitors and bone mineral density in patients with AS. While some studies suggest a potential for bone loss, others point towards a positive impact on bone health. This underscores the need for careful monitoring and individualised management of bone health in patients receiving TNF-alpha inhibitors. The study, which pooled data from multiple studies, showed a mixed picture regarding the effects of TNF-alpha inhibitors on bone mineral density in patients with AS.

Ankylosing Spondylitis: Navigating the Journey Towards Relief

This study, like a compass guiding a traveler through the desert, highlights the importance of a multi-faceted approach to managing AS. It emphasizes the need for close monitoring of bone health in patients receiving TNF-alpha inhibitors and tailoring treatment plans to address individual needs. This research underscores the importance of understanding the complex interplay between inflammation, bone health, and medication in patients with AS.

Dr.Camel's Conclusion

This study, like a shimmering mirage in the desert, reveals the need for a balanced approach to managing ankylosing spondylitis. While TNF-alpha inhibitors can be effective in treating inflammation, their impact on bone health warrants careful consideration. It's crucial to work closely with your healthcare provider to ensure that you're receiving the best possible care and managing your bone health effectively.

Date :
  1. Date Completed 2015-07-21
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

24909809

DOI: Digital Object Identifier

10.1016/j.semarthrit.2014.05.008

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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