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Effects of eflornithine hydrochloride (DFMO) on fetal development in rats and rabbits.

Author: GibsonJ P, HuffmanK W, O'TooleB A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Eflornithine hydrochloride, an inhibitor of L-ornithine decarboxylase, was found to be embryotoxic in rats and rabbits. Maternal food and water consumption and body weight gain were reduced at high doses, and all implantations were aborted or resorbed. At lower doses, fetuses survived to term but with reduced numbers and lower average weight.
Paper Details　
Original Abstract of the Article :
Eflornithine hydrochloride (DFMO) is a highly selective, enzyme-activated, irreversible inhibitor of the enzyme L-ornithine decarboxylase (ODC). Because of its role in the biosynthetic pathway of polyamines, ODC is essential for the growth and development of newly implanted embryonic tissue. In orde...See full text at original site
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引用元：
https://doi.org/10.1002/tera.1420390202

データ提供：米国国立医学図書館（NLM）

Eflornithine Hydrochloride: A Crucial Role in Fetal Development

Eflornithine hydrochloride (DFMO), a potent inhibitor of the enzyme ornithine decarboxylase (ODC), plays a crucial role in regulating polyamine biosynthesis, which is essential for cell growth and development. This study investigated the effects of DFMO on fetal development in pregnant rats and rabbits. The researchers explored the impact of DFMO on embryonic growth and fetal development at various stages of gestation, seeking to understand the critical role of polyamines in normal embryonic development.

Eflornithine Hydrochloride: A Double-Edged Sword for Fetal Development

The study found that DFMO, when administered at high doses, caused significant embryotoxicity and growth retardation in both rats and rabbits. At lower doses, fetuses survived to term, but with reduced numbers and significantly lower average fetal weights. These findings underscore the critical role of polyamines in normal embryonic development and the potential risks associated with inhibiting ODC activity. However, it's important to note that DFMO is not commonly used in pregnant women, and these findings are primarily of academic interest.

The Importance of Polyamines in Fetal Development

This study provides valuable insights into the critical role of polyamines in normal embryonic development. It highlights the potential consequences of disrupting polyamine biosynthesis, underscoring the importance of maintaining adequate polyamine levels for proper fetal growth and development.

Dr.Camel's Conclusion

This study, like a desert expedition revealing the secrets of a forgotten civilization, unveils the crucial role of polyamines in fetal development. It reminds us that even subtle changes in metabolic processes can have profound implications for embryonic growth and development. As we continue to explore the intricate mechanisms that govern life, we must remain vigilant in understanding the potential impact of therapeutic interventions on the delicate balance of biological systems.

Date :
  1. Date Completed 1989-04-28
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2494758

DOI: Digital Object Identifier

10.1002/tera.1420390202

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Languages

English

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