Paper Details

  1. Home
  2. Paper Details

Collagen membrane wrapping around methotrexate-containing calcium-phosphate cement reduces the side effects on soft tissue healing.

Author: AkkayaSemih, AkmanAlp, DemirkanA Fahir, DoğuGamze Gököz, UzunAnıl S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Wrapping a collagen membrane around methotrexate (MTX)-containing calcium-phosphate cement (CPC) reduced the side effects of MTX on soft tissue healing, particularly at high MTX concentrations. This could potentially allow for the administration of higher doses of MTX.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: This study aims to evaluate whether the collagen membrane (membrane) wrapping around the methotrexate (MTX)-containing calcium-phosphate cement (CPC) reduces the side effects on soft tissue healing. MATERIAL AND METHODS: In 36 rats, femoral bone defects were created and treated in six g...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.5606/ehc.2014.21

データ提供：米国国立医学図書館（NLM）

Collagen Membrane Wrapping: A Protective Shield for Soft Tissue Healing

Methotrexate (MTX), a commonly used anti-neoplastic drug, can have detrimental effects on soft tissue healing. This research explores the potential of collagen membrane wrapping in mitigating the side effects of MTX on soft tissue healing. The study aimed to evaluate the impact of collagen membrane wrapping on the healing process in bone defects treated with MTX-containing calcium-phosphate cement (CPC).

Collagen Membrane: A Protective Layer in Bone Healing

The research findings suggest that collagen membrane wrapping can effectively reduce the negative effects of MTX on soft tissue healing. The study demonstrated that membrane wrapping significantly improved healing in the connective tissue samples of the CPC containing 5% MTX group, minimizing the detrimental effects of MTX on cellular proliferation. This is akin to a protective barrier in a desert environment, shielding delicate plant life from harsh conditions.

Navigating the Desert of Bone Healing

The research underscores the importance of optimizing bone healing strategies, particularly in cases involving anti-neoplastic drugs. This research, like a well-equipped caravan traversing a challenging desert, provides valuable insights into the potential of collagen membrane wrapping in promoting bone healing and minimizing the negative effects of MTX.

Dr.Camel's Conclusion

This study investigates the potential of collagen membrane wrapping in mitigating the side effects of MTX on soft tissue healing, suggesting a promising strategy for optimizing bone healing outcomes. This research, like a hidden oasis in a vast and unforgiving desert, offers a novel approach to protecting delicate tissues and promoting healing.
Date :
  1. Date Completed 2016-02-22
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25036396

DOI: Digital Object Identifier

10.5606/ehc.2014.21

Related Literature

Article Analysis
・Side Effects of calcium
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.