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Novel stereoselective high-performance liquid chromatographic method for simultaneous determination of guaifenesin and ketorolac enantiomers in human plasma.

Author: Al-TaweelShorog M, AlshehriMona M, AlzomanNourah Z, MaherHadir M

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study describes a new method for measuring the levels of guaifenesin and ketorolac in blood samples. Guaifenesin is a medication that is often used to treat coughs. Ketorolac is a pain reliever. This method can be used to monitor the levels of these drugs in patients who are taking them together.
Paper Details　
Original Abstract of the Article :
A novel method was developed for the simultaneous determination of guaifenesin (GUA) and ketorolac tromethamine (KET) enantiomers in plasma samples. Since GUA probably increases the absorption of coadministered drugs (e.g., KET), it would be extremely important to monitor KET plasma levels for the p...See full text at original site
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引用元：
https://doi.org/10.1002/chir.22354

データ提供：米国国立医学図書館（NLM）

Unlocking the Secrets of Drug Interactions: A New Method for Analyzing Enantiomers

The intricate world of drug interactions is a constant source of intrigue for researchers. This study introduces a novel high-performance liquid chromatography (HPLC) method for simultaneously determining the enantiomers of guaifenesin (GUA) and ketorolac tromethamine (KET) in plasma samples. This method promises to improve our understanding of drug interactions by providing a more precise analysis of enantiomers, which can exhibit distinct pharmacological properties. The findings of this study could significantly enhance the precision and safety of drug administration, especially in situations where drug interactions are a concern.

Enantiomers: A Tale of Two Twins

The study highlights the importance of considering the different properties of enantiomers, which are like mirror images of each other but can have different effects on the body. This innovative method for analyzing enantiomers could lead to more personalized drug therapy, where dosages are tailored to an individual's specific needs and responses.

A Precision Revolution in Drug Therapy: The Impact of Enantiomer Analysis

The ability to analyze enantiomers with greater precision has the potential to revolutionize drug therapy. By understanding the specific effects of each enantiomer, we can develop more targeted and effective treatments, minimizing side effects and maximizing patient outcomes. It's like having a map that guides us through the complexities of drug interactions, ensuring a smoother journey for patients.

Dr. Camel's Conclusion

The development of this innovative HPLC method for enantiomer analysis is a testament to the ongoing quest for precision in drug therapy. By analyzing enantiomers with greater accuracy, we can achieve a more tailored and personalized approach to medicine. It's like navigating the vast desert of drug interactions with a compass that points us in the right direction, leading to more effective and safer treatments for patients.

Date :
  1. Date Completed 2015-06-02
  2. Date Revised 2014-09-26
Further Info :

Pubmed ID

25043279

DOI: Digital Object Identifier

10.1002/chir.22354

SNS
PICO Info
in preparation
Languages

English

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