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Inhibitory action of alpha-difluoromethylornithine on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced rat urinary bladder carcinogenesis.

Author: OyasuR, RademakerA, SeidenfeldJ, UchidaK

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

DFMO, an ornithine decarboxylase inhibitor, suppressed rat urinary bladder carcinogenesis. The suppressive effect was stage-specific and lasted with continuous treatment. DFMO showed potential as a chemopreventive agent for human superficial bladder cancer.
Paper Details　
Original Abstract of the Article :
We previously have shown that urine components capable of stimulating ornithine decarboxylase activity of urothelium can enhance rat urinary bladder carcinogenesis, and that alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, suppresses carcinogen-initiated ra...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2504487

データ提供：米国国立医学図書館（NLM）

Alpha-Difluoromethylornithine: A Promising Tool in the Fight Against Bladder Cancer

Bladder cancer is a serious health concern, and finding effective treatment strategies is crucial. This research explores the potential of alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, as a chemopreventive agent for bladder cancer. The study investigated the effect of DFMO on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder carcinogenesis in rats.

DFMO's Impact: Suppression of Bladder Cancer Growth

The study revealed that continuous treatment with DFMO significantly reduced tumor formation in rats. This finding suggests that DFMO may have potential as a chemopreventive agent for bladder cancer.

Cancer Prevention: A Multi-Faceted Approach

This research highlights the potential of DFMO in bladder cancer prevention. However, it is essential to note that this study was conducted in rats, and further research is needed to determine its efficacy and safety in humans.

Dr. Camel's Conclusion

This study suggests that DFMO might be a promising camel in the fight against bladder cancer! Its ability to suppress tumor growth is encouraging, but we need to trek further into the desert of research to understand its full potential in humans. Remember, prevention is always the best medicine, and this study offers a glimpse of hope for a future where bladder cancer can be effectively tackled.

Date :
  1. Date Completed 1989-10-05
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2504487

DOI: Digital Object Identifier

2504487

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・Side Effects of eflornithine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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