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Involvement of microRNA181a in differentiation and cell cycle arrest induced by a plant-derived antioxidant carnosic acid and vitamin D analog doxercalciferol in human leukemia cells.

Author: DuggalJyoti, HarrisonJonathan S, StudzinskiGeorge P, WangXuening

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Doxercalciferol (1-D2) is a drug that is being investigated as a treatment for acute myeloid leukemia (AML). This study found that 1-D2 could induce differentiation of AML cells, which means that the cells become more like normal blood cells. The study also found that carnosic acid, a plant-derived antioxidant, could enhance the effects of 1-D2. This study suggests that 1-D2, with or without carnosic acid, could be a promising new treatment for AML.
Paper Details　
Original Abstract of the Article :
1,25-dihydroxyvitamin D3 (1,25D) has been shown to influence differentiation, cell proliferation and cell death in cultured leukemia cells. However, its clinical use is limited by its hypercalcemic effects. An analog of 1,25D, doxercalciferol (1-D2), has anti-tumor activity, with markedly reduced ca...See full text at original site
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引用元：
https://doi.org/10.2174/2211536611201010026

データ提供：米国国立医学図書館（NLM）

MicroRNA181a: A Key Regulator of Differentiation and Cell Cycle Arrest in Leukemia

Leukemia, a formidable foe in the fight against cancer, continues to demand our attention. This research, like a camel navigating a treacherous dune field, explores the role of microRNA181a in differentiation and cell cycle arrest induced by carnosic acid and doxercalciferol in leukemia cells. The study reveals that the combination of carnosic acid, a plant-derived antioxidant, and doxercalciferol, a vitamin D analog, effectively induces differentiation and cell cycle arrest in leukemia cells, potentially offering a new therapeutic strategy for combating this disease.

MicroRNA181a: A Potential Target for Leukemia Treatment

The study highlights the crucial role of microRNA181a in mediating the anti-leukemic effects of carnosic acid and doxercalciferol. The researchers demonstrated that modulation of microRNA181a levels significantly impacted the effectiveness of these agents, suggesting that this microRNA could serve as a potential target for future leukemia treatments.

Leukemia and MicroRNA181a: Exploring the Desert of Cancer Biology

This research opens a new avenue for understanding and treating leukemia. Further investigations are needed to fully elucidate the complex interactions between microRNA181a, carnosic acid, and doxercalciferol in leukemia cells. However, the study provides a promising foundation for developing novel therapies that could potentially improve the lives of patients battling this devastating disease.

Dr.Camel's Conclusion

The desert of cancer biology is vast and often unforgiving, but we are constantly uncovering new pathways for understanding and treating this disease. This research reminds us of the power of natural compounds and the intricate role of microRNAs in cellular processes. Through continued exploration and innovation, we can illuminate the path towards effective treatments and ultimately conquer the challenges of leukemia.

Date :
  1. Date Completed 2014-12-11
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

25048087

DOI: Digital Object Identifier

10.2174/2211536611201010026

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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