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Bone mineral density in ambulatory children with epilepsy.

Author: Abdollah GorjiFatemeh, Ahmad AbadiFarzad, Amir ShahkaramiSeyed Mohammad, ShariatFakhredin, TonekaboniSeyed Hasan, YaghiniOmid

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Both enzyme-inducing AEDs and non enzyme-inducing AEDs decrease bone mineral density (BMD) and affect alkaline phosphatase (ALP) in ambulatory epileptic children. Valproic acid (a non-enzyme-inducing agent) does not have these side effects.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To elucidate the effects of antiepileptic drugs (AEDs) on bone health status of ambulatory epileptic children. METHODS: A total of 120 epileptic children aged 2-15 y were enrolled in three groups. The first group was on therapy with carbamazepine, phenobarbital or primidone. The second w...See full text at original site
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引用元：
https://doi.org/10.1007/s12098-014-1518-0

データ提供：米国国立医学図書館（NLM）

Bone Health in Children with Epilepsy: A Desert Oasis of Understanding

Epilepsy, a neurological disorder characterized by seizures, can affect individuals of all ages. Children with epilepsy often require medication to manage their condition, and these medications can sometimes have unintended side effects. This study, like a desert oasis providing insights into the complexities of epilepsy, investigated the impact of antiepileptic drugs (AEDs) on bone health in children with epilepsy. The researchers compared bone mineral density (BMD) in children taking different AEDs to those not taking AEDs.

AEDs and Bone Health: Navigating a Desert of Side Effects

The study found that both enzyme-inducing AEDs and non-enzyme-inducing AEDs could decrease BMD in children with epilepsy. This suggests that AEDs, while necessary for seizure control, can have a negative impact on bone health, potentially increasing the risk of fractures.

Supporting Bone Health: A Desert Traveler's Guide

This research highlights the importance of monitoring bone health in children with epilepsy. Healthcare providers should be aware of the potential side effects of AEDs on bone density and take appropriate measures to minimize these risks. These measures might include regular monitoring of BMD, ensuring adequate calcium and vitamin D intake, and considering alternative AEDs that have a lower impact on bone health.

Dr.Camel's Conclusion

This study, like a desert oasis revealing hidden truths, highlights the potential impact of AEDs on bone health in children with epilepsy. By understanding these risks, healthcare providers can take proactive steps to ensure the well-being of their patients, promoting strong bones and a healthy future for children with epilepsy.

Date :
  1. Date Completed 2016-11-11
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

25106841

DOI: Digital Object Identifier

10.1007/s12098-014-1518-0

Related Literature

Article Analysis
・Side Effects of primidone
SNS
PICO Info
in preparation
Languages

English

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