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High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors.

Author: BuglioniSabrina, CarocciFrancesca, FaisStefano, FanciulliMaurizio, FrancescoMenicagli, SpugniniEnrico P, VincenziBruno

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The treatment of human cancer has been hampered by resistance to chemotherapeutic drugs. This study investigated the efficacy of combining metronomic chemotherapy with high dose proton-pump inhibitors (PPIs) in treating pets with spontaneously occurring cancer.
Paper Details　
Original Abstract of the Article :
The treatment of human cancer has been seriously hampered for decades by resistance to chemotherapeutic drugs. A very efficient mechanism of tumor resistance to drugs is the proton pumps-mediated acidification of tumor microenvironment. Metronomic chemotherapy has shown efficacy in adjuvant fashion ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145230/

データ提供：米国国立医学図書館（NLM）

High Dose Lansoprazole and Metronomic Chemotherapy: A New Frontier in Cancer Treatment

[Cancer] is a devastating disease that continues to pose a significant challenge for researchers and clinicians. This study investigates the potential of combining [high-dose lansoprazole], a proton pump inhibitor, with [metronomic chemotherapy] in the treatment of [spontaneously occurring tumors] in companion animals. The researchers hypothesize that lansoprazole, by inhibiting the acidification of the tumor microenvironment, could enhance the effectiveness of chemotherapy. Their preliminary findings suggest that this combination therapy may be a promising approach, warranting further investigation.

A New Oasis in Cancer Treatment: Combining Forces for Greater Impact

The study found that the combination of high-dose lansoprazole and metronomic chemotherapy showed promising results in companion animals with cancer. This is like finding a hidden oasis in the desert, offering a new and potentially more effective approach to fighting cancer. The study suggests that this combination therapy may be a valuable tool for treating cancer, especially in cases where conventional treatments have failed.

Harnessing the Power of the Microenvironment: A New Avenue for Cancer Research

The desert teaches us that even the smallest details can have a significant impact on survival. This study highlights the importance of understanding the role of the tumor microenvironment in cancer treatment. By targeting the acidic environment of the tumor, this combination therapy may enhance the effectiveness of chemotherapy, offering hope for improved treatment outcomes.

Dr.Camel's Conclusion

This study explores the potential of combining high-dose lansoprazole with metronomic chemotherapy as a promising approach for treating cancer. The findings suggest that this combination therapy could be a valuable tool for addressing the challenges of cancer treatment, offering a new avenue for research and potential breakthroughs.

Date :
  1. Date Completed 2015-05-26
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

25143012

DOI: Digital Object Identifier

PMC4145230

Related Literature

Article Analysis
・Side Effects of lansoprazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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