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The enzyme-activated irreversible inhibitor of ornithine decarboxylase, DL-alpha-difluoromethylornithine: a chemopreventive agent.

Author: VermaA K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

DFMO, an enzyme inhibitor, showed potential in preventing cancer in animal models. However, higher doses of DFMO have led to side effects like thrombocytopenia and ototoxicity. Smaller doses might be safer for long-term use in humans. Further evaluation in human cancer prevention trials is needed.
Paper Details　
Original Abstract of the Article :
DL-alpha-Difluoromethylornithine (DFMO) is an enzyme-activated irreversible inhibitor of mammalian ornithine decarboxylase. DFMO, when administered in drinking water, precludes increases in the levels of intracellular putrescine and spermidine and also inhibits the induction of skin, breast, colon, ...See full text at original site
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引用元：
https://doi.org/10.1016/0091-7435(89)90035-2

データ提供：米国国立医学図書館（NLM）

DFMO: A Potential Cancer Prevention Weapon

The fight against [cancer] is an ongoing battle, with researchers tirelessly searching for effective preventative measures. This research explores the [chemopreventive potential] of [DL-alpha-difluoromethylornithine (DFMO)], a compound that inhibits the enzyme [ornithine decarboxylase] which plays a role in cell growth and proliferation. The researchers investigated the effects of [DFMO] in various animal models and discovered its ability to [inhibit the development of various types of cancers]. The findings suggest that [DFMO] may hold promise as a [cancer prevention agent] for humans.

DFMO: Balancing Benefits and Risks

While promising, [DFMO] also exhibits [toxic side effects] at higher doses. The research highlights the need to carefully balance the [potential benefits] of [DFMO] with its [potential risks]. The authors propose using lower doses for extended periods to optimize its [chemopreventive effect] while minimizing side effects. This research calls for further investigation into [DFMO] as a potential [cancer prevention agent], emphasizing the need for thorough testing and clinical trials to ensure its safety and efficacy for human use.

The Desert Oasis of Cancer Prevention

This research provides a glimpse into the vast desert of cancer prevention research. The authors offer a glimmer of hope by highlighting the potential of [DFMO] as a tool in our fight against this insidious disease. Just as a desert oasis provides life-sustaining water, this research suggests that [DFMO] may offer a vital pathway to cancer prevention. However, we must continue to explore and refine this potential tool to ensure its effectiveness and safety for human use.

Dr. Camel's Conclusion

While [DFMO] shows potential for cancer prevention, the research underscores the importance of carefully evaluating its effectiveness and safety. As we continue to explore this arid landscape of cancer prevention, we must navigate cautiously, seeking to find the oasis of a safe and effective solution.

Date :
  1. Date Completed 1990-03-05
  2. Date Revised 2019-09-12
Further Info :

Pubmed ID

2515533

DOI: Digital Object Identifier

10.1016/0091-7435(89)90035-2

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Languages

English

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