A potential effect of ganaxolone in an animal model of infantile spasms.

Author: KoTae-Sung, LeeMinyoung, VelíšekLibor, YumMi-Sun

Paper Details 
Original Abstract of the Article :
Infantile spasms (IS), a devastating epileptic encephalopathy of infancy, involve various etiologies associated with an unknown underlying common pathophysiology. The efficacy of adrenocorticotropic hormone (ACTH) as an IS therapy suggests a role for steroid hormones in treating IS. This study used ...See full text at original site
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引用元:
https://doi.org/10.1016/j.eplepsyres.2014.08.015

データ提供:米国国立医学図書館(NLM)

Ganaxolone: A Potential Treatment for Infantile Spasms

Infantile spasms (IS), a severe form of epilepsy in infants, can have devastating effects on development. This study explores the potential of ganaxolone, a synthetic neurosteroid, as a treatment for IS.

Ganaxolone: A Promising Agent for IS Treatment

The authors used an animal model of IS to evaluate the efficacy of ganaxolone, which promotes GABAergic inhibition, a process involved in regulating neuronal activity. Their findings suggest that ganaxolone may have therapeutic potential for IS. This research is promising, as it provides a potential new treatment option for a devastating condition with limited effective therapies.

Navigating the Desert of Neurological Disorders: Seeking New Solutions

This research, much like a camel navigating a challenging desert, highlights the ongoing search for effective treatments for complex neurological disorders. Ganaxolone, like a hidden oasis in the vast desert of neurological research, offers a potential new solution for IS. This research encourages further exploration of ganaxolone's therapeutic potential in human clinical trials, with the hope of improving the lives of infants affected by this debilitating condition.

Dr. Camel's Conclusion

This research, like a camel discovering a promising water source in a desolate desert, provides a glimmer of hope for infants suffering from infantile spasms. Ganaxolone, a synthetic neurosteroid, has shown potential in an animal model, suggesting a possible new avenue for treatment. This research encourages further exploration of ganaxolone's potential in human clinical trials, offering the possibility of improving the lives of these vulnerable infants.

Date :
  1. Date Completed 2015-06-08
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

25219352

DOI: Digital Object Identifier

10.1016/j.eplepsyres.2014.08.015

Related Literature

SNS
PICO Info
in preparation
Languages

English

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