Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials.

Author: ChenXiaorong, LuYunfei, XuQingnian, YangZongguo, ZhuangLiping

Paper Details 
Original Abstract of the Article :
OBJECTIVE: This study aimed to evaluate the efficacy and safety of silymarin on chronic hepatitis C virus- (HCV-) infected patients. METHODS: Randomized controlled trials (RCTs) of silymarin in chronic HCV-infected patients up to April 1, 2014 were systematically identified in PubMed, Ovid, Web of ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163440/

データ提供:米国国立医学図書館(NLM)

Silymarin for Chronic Hepatitis C: A Desert Mirage?

Silymarin, derived from milk thistle, has been studied for its potential therapeutic benefits for chronic hepatitis C virus (HCV) infection. This study embarks on a meta-analysis of randomized controlled trials to evaluate the efficacy and safety of silymarin in HCV-infected patients. The researchers combed through published studies up to April 1, 2014, meticulously examining the findings.

The researchers, like seasoned desert explorers, carefully analyzed the data, concluding that silymarin is well-tolerated in chronic HCV-infected patients. However, their findings, like a mirage in the desert, failed to demonstrate a clear benefit in terms of reducing HCV RNA levels or improving liver function.

Navigating the Uncertainties of HCV

This study, like a desert caravan navigating shifting sands, reminds us that the path to treating chronic HCV infection is fraught with uncertainties. While silymarin appears safe, its efficacy remains unclear, highlighting the need for continued research.

A Complex and Challenging Journey

The desert of HCV research is vast and challenging. This study, like a well-marked trail, provides valuable information about the potential benefits and risks of silymarin for HCV-infected patients. The journey toward effective treatments continues, and further research is needed to fully understand the role of silymarin.

Dr.Camel's Conclusion

While silymarin is well-tolerated, the study failed to demonstrate a clear benefit in terms of reducing HCV RNA levels or improving liver function. This study emphasizes the complexity of HCV infection and the need for continued research to develop effective treatments.

Date :
  1. Date Completed 2015-06-15
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

25247194

DOI: Digital Object Identifier

PMC4163440

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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