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Effects of multiple-dose rifampicin 450 mg on the pharmacokinetics of fexofenadine enantiomers in Japanese volunteers.

Author: AkamineY, IeiriI, MiuraM, UnoT, Yasui-FurukoriN

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the effects of multiple doses of rifampicin 450 mg on the pharmacokinetics of fexofenadine enantiomers in healthy Japanese volunteers. Rifampicin is known to induce P-glycoprotein and inhibit OATP transporters, while fexofenadine is a substrate for both mechanisms. The study aims to determine the impact of rifampicin 450 mg on fexofenadine levels in the body.
Paper Details　
Original Abstract of the Article :
Rifampicin is a potent inducer of P-glycoprotein (P-gp) and inhibitor of organic anion-transporting polypeptides (OATPs), with fexofenadine acting as a substrate for both mechanisms. Simultaneous administration of single- or multiple-dose rifampicin 600 mg significantly increases the concentrations ...See full text at original site
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引用元：
https://doi.org/10.1111/jcpt.12213

データ提供：米国国立医学図書館（NLM）

Rifampicin and Fexofenadine: A Pharmacokinetic Puzzle

The world of pharmacokinetics is a complex and intricate landscape, where the interaction of different drugs can have unexpected consequences. This study explores the impact of rifampicin, a potent inducer of certain enzymes, on the pharmacokinetics of fexofenadine, an antihistamine.

A Pharmacokinetic Dance: Interactions Unveiled

The study revealed that rifampicin can significantly influence the pharmacokinetics of fexofenadine, potentially affecting its efficacy and safety. It's like a delicate dance between two travelers in the desert, where the actions of one can impact the journey of the other. This complex interplay highlights the importance of understanding drug interactions to ensure optimal treatment outcomes.

Navigating the Pharmacokinetic Landscape: A Call for Caution

This study underscores the importance of carefully considering drug interactions when prescribing medications. Understanding how rifampicin can influence the pharmacokinetics of fexofenadine is crucial for ensuring patient safety and maximizing treatment effectiveness. This knowledge, like a trusty compass guiding a caravan through the desert, can help medical professionals navigate the complex world of drug interactions.

Dr. Camel's Conclusion

This study, like a camel meticulously navigating a path through the desert, uncovers the intricate interplay between rifampicin and fexofenadine. Understanding these pharmacokinetic interactions is crucial for ensuring patient safety and optimizing treatment outcomes, much like a skilled caravan guide ensures a smooth and successful journey through the vast and challenging desert.

Date :
  1. Date Completed 2015-08-06
  2. Date Revised 2015-01-05
Further Info :

Pubmed ID

25263393

DOI: Digital Object Identifier

10.1111/jcpt.12213

Related Literature

Article Analysis
・Effects of fexofenadine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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