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Randomized dose range study of a recombinant hepatitis B vaccine produced in mammalian cells and containing the S and PreS2 sequences.
Author: AdamowiczP, BenhamouJ P, BréchotC, CouroucéA M, DegosF, GoudeauA, LaplancheA, MarieF N, SaliouP, TronF
Original Abstract of the Article :
The safety and immunogenicity of different doses (2, 5, 10, and 20 micrograms of a recombinant hepatitis B virus (rHBV) vaccine containing the S and PreS2 sequences and produced in mammalian cells were compared to those of a plasma-derived hepatitis B virus vaccine (Hevac B Pasteur) in 482 volunteer...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1093/infdis/160.2.199
データ提供:米国国立医学図書館(NLM)
Recombinant Hepatitis B Vaccine: A New Oasis in the Desert of Viral Prevention
Hepatitis B is a serious viral infection that can lead to liver damage and other health problems. This study investigates the safety and immunogenicity of a new recombinant hepatitis B vaccine produced in mammalian cells. The researchers compared different doses of this vaccine to a plasma-derived vaccine, aiming to determine the optimal dose for effective immunization.
A Promising New Vaccine: A Beacon of Hope in the Desert of Hepatitis B
The study found that the new recombinant hepatitis B vaccine was safe and immunogenic, with similar seroconversion rates to the plasma-derived vaccine. The researchers concluded that the 10- and 20-microgram doses of the recombinant vaccine were as effective as the plasma-derived vaccine and elicited higher antibody levels compared to lower doses. The recombinant vaccine also showed an advantage in terms of early and high production of antibodies to PreS2, a protein associated with viral entry.
Protecting Against Hepatitis B: A Journey Towards Healthier Futures
This research offers a potential new weapon in the fight against hepatitis B. It's like discovering a new oasis in the vast desert of viral infections. The study's findings suggest that the new recombinant vaccine is safe and effective, potentially leading to better protection against this serious disease. It's a reminder that innovation and research continue to offer hope for healthier futures.
Dr.Camel's Conclusion
This research highlights the potential of a new recombinant hepatitis B vaccine to offer effective protection against this serious infection. It's like discovering a new oasis in the vast desert of viral infections. The study's findings suggest that this vaccine could be a valuable tool for preventing hepatitis B, offering hope for a healthier future.
Date :
- Date Completed 1989-09-08
- Date Revised 2019-05-10
Further Info :
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