Paper Details
- Home
- Paper Details
Potential association between rosuvastatin use and high atazanavir trough concentrations in ritonavir-treated HIV-infected patients.
Author: CattaneoDario, ClementiEmilio, GalliMassimo, GervasoniCristina, RivaAgostino, RizzardiniGiuliano
Original Abstract of the Article :
Emerging evidence shows that standard atazanavir (ATV) dosages are associated with considerable interindividual variability in plasma drug concentrations. Given the potential impact of ATV exposure on clinical outcome, in this retrospective study we sought to assess demographic and clinical factors ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.3851/IMP2872
データ提供：米国国立医学図書館（NLM）
Rosuvastatin and Atazanavir: A Case of Drug Interactions in the HIV Desert
The treatment of HIV infection requires a delicate balance, with medications aiming to suppress the virus while minimizing side effects. This research explores the potential impact of rosuvastatin, a cholesterol-lowering drug, on the effectiveness of atazanavir (ATV), a crucial antiretroviral medication used in the treatment of HIV. The authors investigated factors influencing ATV plasma concentrations in a large cohort of HIV-infected patients, uncovering a potential association between rosuvastatin use and higher ATV trough concentrations.
Navigating the Shifting Sands of Drug Interactions
The study suggests that rosuvastatin might interfere with the metabolism of ATV, leading to higher levels of the drug in the bloodstream. While higher levels of ATV could potentially enhance its antiviral effectiveness, it also raises concerns about potential side effects. The authors emphasize the importance of monitoring ATV plasma concentrations in patients taking rosuvastatin to ensure optimal treatment and minimize potential risks.
A Camel's Reminder: The Importance of Personalized Care
This research is a reminder that even seemingly unrelated medications can interact in ways that may affect the effectiveness of treatment. It underscores the importance of thorough patient history and careful consideration of potential drug interactions, particularly in complex medical conditions like HIV infection.
Dr. Camel's Conclusion
The desert of HIV treatment is vast and complex, with numerous medications and potential interactions to consider. We must approach treatment with a keen eye for detail, paying attention to each patient's unique circumstances and potential drug interactions. This research reminds us that collaborative efforts between physicians and pharmacists are crucial in ensuring effective and safe treatment for all our patients.
Date :
- Date Completed 2016-04-12
- Date Revised 2015-07-21
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.