Miconazole buccal gel and risk for systemic bleeding: how certain topical formula can interfere with anticoagulants.

Author: De BackerT, De PauwA

Paper Details 
Original Abstract of the Article :
The association of miconazole and oral anticoagulants should be carried out with great caution because of potentially serious side effects. This phenomenon is well known in the case of systemic administration of miconazole, but there is limited awareness that also topical oral administration of mico...See full text at original site
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引用元:
https://doi.org/10.1179/2295333714Y.0000000089

データ提供:米国国立医学図書館(NLM)

Miconazole Buccal Gel: A Cautionary Tale for Anticoagulant Users

Miconazole, a common antifungal medication, is often used topically for oral candidiasis. However, this study highlights a potential risk associated with the use of miconazole buccal gel in patients taking oral anticoagulants. The researchers describe four cases where patients using miconazole buccal gel experienced an increase in their international normalized ratio (INR), a measure of blood clotting time. These cases underscore the importance of careful monitoring and potential drug interactions when using miconazole buccal gel in patients on anticoagulants. Clinicians should be aware of this potential interaction and exercise caution when prescribing miconazole buccal gel to patients taking anticoagulants.

Miconazole Buccal Gel: A Potential Pitfall for Anticoagulant Users

The study highlights a potential drug interaction between miconazole buccal gel and oral anticoagulants. The researchers report cases where patients using miconazole buccal gel experienced increased INR levels, suggesting a potential risk of bleeding complications. This finding underscores the importance of careful monitoring and awareness of this potential interaction when prescribing miconazole buccal gel to patients on anticoagulants.

Navigating the Terrain of Drug Interactions: Ensuring Patient Safety

Drug interactions can occur when different medications are taken together, potentially leading to unexpected and even harmful effects. This study underscores the importance of careful medication management and awareness of potential interactions. Healthcare professionals should exercise vigilance when prescribing medications, especially in patients taking multiple medications or those with complex medical histories. Open communication and thorough patient education are crucial in ensuring patient safety.

Dr. Camel's Conclusion

Navigating the complex world of medications is like traversing a vast desert, where each dune represents a potential interaction. This study serves as a reminder that even seemingly innocuous medications like miconazole buccal gel can have unforeseen effects when combined with other drugs. By carefully monitoring patients and remaining vigilant about potential interactions, healthcare professionals can ensure patient safety and optimize treatment outcomes.

Date :
  1. Date Completed 2015-08-13
  2. Date Revised 2016-03-07
Further Info :

Pubmed ID

25331621

DOI: Digital Object Identifier

10.1179/2295333714Y.0000000089

Related Literature

SNS
PICO Info
in preparation
Languages

English

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