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Differential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirine.

Author: ChangThomas K H, LauAik Jiang, SharmaDevinder, ShermanMatthew A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of second-generation non-nucleoside reverse transcriptase inhibitors (NNRTIs) on the activity of the constitutive androstane receptor (CAR). Rilpivirine and etravirine were found to be less potent inhibitors of CAR activity than first-generation NNRTIs (efavirenz, nevirapine, and delavirdine).
Paper Details　
Original Abstract of the Article :
Rilpivirine and etravirine are second-generation non-nucleoside reverse transcriptase inhibitors (NNRTIs) indicated for the treatment of HIV/AIDS. The constitutive androstane receptor (CAR) regulates the expression of genes involved in various biological processes, including the transport and biotra...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337700/

データ提供：米国国立医学図書館（NLM）

Differential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirine

HIV/AIDS is a serious global health concern, and rilpivirine and etravirine are two non-nucleoside reverse transcriptase inhibitors (NNRTIs) used to treat the disease. This study investigates the effects of these drugs on the human constitutive androstane receptor (CAR), a key regulator of drug metabolism. The authors examined the activation of CAR and its splice variants by rilpivirine and etravirine, comparing their effects to first-generation NNRTIs. They discovered that [主要な発見] This study provides valuable insights into the interactions between NNRTIs and CAR, which could have implications for drug development and patient management.

NNRTIs and CAR: A Complex Relationship

This study highlights that [社会的な意義] The authors' findings emphasize the importance of considering the potential impact of NNRTIs on CAR activation, particularly when developing new drug therapies for HIV/AIDS.

HIV/AIDS Treatment: A Careful Balancing Act

Effective treatment for HIV/AIDS involves careful consideration of drug interactions and potential side effects. This study suggests that [健康的なベネフィットもしくはリスク] It's essential to collaborate closely with your doctor to ensure that your HIV/AIDS treatment plan is tailored to your individual needs and minimizes potential risks.

Dr.Camel's Conclusion

Think of the human body as a complex desert ecosystem, with various receptors playing vital roles in maintaining balance. This study explores the interaction between NNRTIs and CAR, two key players in this delicate ecosystem. It's like understanding how different types of sand dunes can influence the flow of water in a desert. This research reminds us that even seemingly unrelated aspects of our biology can be interconnected, and a deep understanding of these interactions is crucial for developing safe and effective drug therapies.

Date :
  1. Date Completed 2016-03-10
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

25363652

DOI: Digital Object Identifier

PMC4337700

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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