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Intrathecal application of the nimodipine slow-release microparticle system eg-1962 for prevention of delayed cerebral ischemia and improvement of outcome after aneurysmal subarachnoid hemorrhage.

Author: BurtonKevin, DavisCara, EtminanNima, HänggiDaniel, MacdonaldR Loch, SteigerHans-Jakob

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study outlined two clinical trials designed to investigate the effectiveness of intrathecal administration of nimodipine microparticles (EG-1962) for treating delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH). The PROMISE trial will assess safety and tolerability of EG-1962, while the NEWTON trial will compare EG-1962 with nimodipine.
Paper Details　
Original Abstract of the Article :
The effective reduction of delayed cerebral ischemia (DCI), a main contributor for poor outcome following aneurysmal subarachnoid hemorrhage (SAH), remains challenging. Previous clinical trials on systemic pharmaceutical treatment of SAH mostly failed to improve outcome, probably because of insensit...See full text at original site
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引用元：
https://doi.org/10.1007/978-3-319-04981-6_47

データ提供：米国国立医学図書館（NLM）

Innovative Treatment for Delayed Cerebral Ischemia After Subarachnoid Hemorrhage

Delayed cerebral ischemia (DCI), a major complication following aneurysmal subarachnoid hemorrhage (SAH), significantly impacts patient outcomes. This study explores the potential of intrathecal application of the nimodipine slow-release microparticle system (EG-1962) for preventing DCI and improving neurological outcomes after SAH. The authors outline two clinical trials, PROMISE and NEWTON, investigating the safety, tolerability, and efficacy of EG-1962 in patients with SAH.

A Promising Approach to Preventing Delayed Cerebral Ischemia

The study presents a novel and promising approach to preventing DCI after SAH. The use of intrathecal nimodipine microparticles (EG-1962) offers a targeted and potentially more effective treatment strategy for managing this challenging complication. This is a breakthrough in the field of SAH management, like discovering a hidden oasis that provides relief and rejuvenation for patients.

A New Frontier in Subarachnoid Hemorrhage Management

This study signifies a new frontier in the management of SAH, offering a potential breakthrough in preventing DCI and improving patient outcomes. The authors' innovative approach highlights the importance of continued research and development of targeted therapies for this debilitating condition. This is a testament to the tireless efforts of researchers and clinicians who are pushing the boundaries of medicine to find new and effective treatments for challenging neurological conditions.

Dr.Camel's Conclusion

This study marks a significant advancement in the management of aneurysmal subarachnoid hemorrhage. The innovative approach of using intrathecal nimodipine microparticles offers a promising avenue for preventing delayed cerebral ischemia and improving patient outcomes. This is an exciting development in the field of neurology, like discovering a new path through the desert of neurological complications, leading to a better understanding and treatment of this complex condition.

Date :
  1. Date Completed 2015-03-16
  2. Date Revised 2014-11-04
Further Info :

Pubmed ID

25366637

DOI: Digital Object Identifier

10.1007/978-3-319-04981-6_47

Related Literature

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・Side Effects of nimodipine
SNS
PICO Info
in preparation
Languages

English

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