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Pharmacological approaches to targeting muscarinic acetylcholine receptors.

Author: MateraCarlo, TataAda M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Muscarinic acetylcholine receptors are involved in various physiological functions and have become targets for drug development due to their potential role in various pathologies, including tumors. While some muscarinic ligands, like xanomeline and cevimeline, have been developed for conditions like Alzheimer's and Sjogren's diseases, the lack of selective ligands has limited therapeutic options. Research is exploring the potential of muscarinic ligands in cancer therapy, as some muscarinic antagonists already used for genitourinary diseases have shown to inhibit tumor growth. Muscarinic receptors also contribute to analgesia. Significant progress in bitopic/dualsteric ligands is promising for the development of more effective and targeted treatments.
Paper Details　
Original Abstract of the Article :
The presence of cholinergic system markers and muscarinic receptor subtypes in several tissues also of nonneuronal type has been largely demonstrated. Acetylcholine, synthesized in the nervous system, can locally contribute to modulate cell proliferation, survival and apoptosis. Considering that the...See full text at original site
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引用元：
https://doi.org/10.2174/1574889809666141120131238

データ提供：米国国立医学図書館（NLM）

Muscarinic Acetylcholine Receptors: A Target for New Therapies

This research explores the potential of [muscarinic acetylcholine receptors (mAChRs)] as targets for [new drug development]. The authors discuss the [role of mAChRs] in a variety of physiological processes and their potential involvement in various pathologies, including [tumors and pain]. This research delves into the complex world of [neurotransmission] and its implications for disease treatment.

Muscarinic Acetylcholine Receptors: A Promising Therapeutic Target

This research highlights the [potential of mAChRs] as targets for [novel therapies]. The authors discuss the development of [muscarinic ligands] for the treatment of a range of conditions, including [Alzheimer's disease, Sjogren's disease, and cancer]. This research underscores the [importance of understanding] the role of mAChRs in health and disease.

Navigating the Complexity of mAChRs

This research reminds us that [the body is a complex system], with [neurotransmitters] playing a crucial role in regulating a wide range of functions. The research highlights the need for [careful and precise targeting] of mAChRs in order to develop [effective and safe therapies] that can address specific health conditions without causing unwanted side effects. This is a reminder that [medical research] is a complex and ongoing process, requiring [careful consideration] of the potential benefits and risks of new therapies.

Dr.Camel's Conclusion

This review of muscarinic acetylcholine receptors provides valuable insights into the [potential of these receptors] as targets for [novel therapies]. The research highlights the [importance of understanding] the complex roles of mAChRs in health and disease, and the need for [further research] to develop [safe and effective treatments] that can leverage the therapeutic potential of these receptors.

Date :
  1. Date Completed 2015-08-19
  2. Date Revised 2019-11-13
Further Info :

Pubmed ID

25413004

DOI: Digital Object Identifier

10.2174/1574889809666141120131238

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Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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