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Safety and immunogenicity of pentavalent rotavirus vaccine in a randomized, double-blind, placebo-controlled study in healthy elderly subjects.

Author: CiarletMax, HeSu, LawrenceJody, MartinJason, MurrayAlexander V, SchödelFlorian

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study assessed the safety and immunogenicity of the live pentavalent rotavirus vaccine (RV5) in healthy elderly adults. RV5 was well tolerated, with 9% of placebo and 27% of RV5 recipients experiencing mild or moderate vaccine-related adverse events. A single dose of RV5 boosted immune responses in this population, suggesting potential for further evaluation as a candidate vaccine for elderly individuals.
Paper Details　
Original Abstract of the Article :
Rotavirus may be an important causative agent of acute gastroenteritis (AGE) in the elderly, a population that is particularly vulnerable due to waning immunity. It is estimated that rotavirus may account for 2-5% of adult gastroenteritis hospitalizations in the United States. This is the first stud...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896773/

データ提供：米国国立医学図書館（NLM）

Protecting the Elderly from Rotavirus: A Desert Oasis of Immunity

Rotavirus can cause severe gastroenteritis, especially in vulnerable populations like the elderly. It's like a desert sandstorm that can leave people feeling weak and dehydrated. This study investigates the safety and effectiveness of the pentavalent rotavirus vaccine in elderly adults.

A Safe Haven: Rotavirus Vaccine for the Elderly

Researchers found that the pentavalent rotavirus vaccine was generally safe and well-tolerated in healthy elderly adults. It's like finding a safe oasis in the desert, offering protection against the threat of rotavirus infection. The vaccine was also found to be immunogenic, boosting the immune system's defenses against the virus.

Strengthening Immunity: Protecting the Elderly from Rotavirus

This study provides valuable insights into the use of rotavirus vaccine in the elderly population. By understanding the safety and efficacy of the vaccine, we can better protect this vulnerable group from the debilitating effects of rotavirus infection.

Dr. Camel's Conclusion

The rotavirus vaccine, a beacon of hope in the desert of aging, provides a safe and effective way to protect elderly adults from this potentially serious infection. It's like finding a well-stocked caravan ready to navigate the challenges of aging, ensuring a healthy and fulfilling journey.

Date :
  1. Date Completed 2015-07-27
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

25424929

DOI: Digital Object Identifier

PMC4896773

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Article Analysis
・Side Effects of rotavirus vaccine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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