Pleiotropic effects of statins on the treatment of chronic periodontitis--a systematic review.

Author: CarvalhoRosimary de Sousa, EstanislauIlanna Mara Gomes, LisboaMario Roberto Pontes, MartinsRicardo Souza, MoreiraMaria Mônica Studart Mendes, TelesPatrícia de Barros, TerceiroIcrólio Ribeiro Colares

Paper Details 
Original Abstract of the Article :
Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase and are an important group of hypolipidaemic drugs, widely used in the treatment of hypercholesterolaemia and cardiovascular disease. Some studies have shown that statins are able to modulate inflammation and alveolar bone los...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456120/

データ提供:米国国立医学図書館(NLM)

Statins and Chronic Periodontitis

Chronic periodontitis, like a persistent desert wind, can erode the foundation of our teeth. This systematic review explores the potential pleiotropic effects of statins, commonly used for cholesterol management, in the treatment of chronic periodontitis. The review examines how statins may modulate inflammation and bone loss in the context of this oral disease.

Statins' Potential Beyond Cholesterol

The review highlights the growing body of evidence suggesting that statins, beyond their cholesterol-lowering effects, may have beneficial effects on periodontitis. This is like finding a hidden oasis in the desert, providing unexpected benefits beyond its initial purpose. Several studies have indicated that statins may modulate inflammation and reduce bone loss, key aspects of periodontitis. These findings suggest that statins might have a therapeutic role in managing this common oral disease.

Further Research Needed

Despite the promising findings, the review emphasizes the need for further research to fully understand the role of statins in the treatment of chronic periodontitis. This is like exploring a vast desert, where more research is needed to unravel the secrets of the landscape. The researchers call for more clinical trials to confirm the efficacy and safety of statins in treating this condition and to determine the optimal dosage and treatment duration.

Dr.Camel's Conclusion

This systematic review provides a compelling overview of the potential benefits of statins in managing chronic periodontitis. The review suggests that statins, like a wise camel adapting to the desert environment, may offer therapeutic benefits beyond their primary function of cholesterol management. Further research is needed to fully explore their role in treating this oral disease and to optimize their use for patients.

Date :
  1. Date Completed 2016-02-22
  2. Date Revised 2023-10-31
Further Info :

Pubmed ID

25444240

DOI: Digital Object Identifier

PMC4456120

Related Literature

SNS
PICO Info
in preparation
Languages

English

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