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Safety and pharmacokinetics of the CIME combination of drugs and their metabolites after a single oral dosing in healthy volunteers.

Author: AlavoineLoubna, ArnaudPhilippe, BeaunePhilippe, BecquemontLaurent, BénechHenri, DelaforgeMarcel, DuvalXavier, Funck-BrentanoChristian, JobSylvie, LenuzzaNatacha, LoriotMarie-Anne, MentréFrance, NarjozCéline, NicolasGrégory, ThévenotEtienne, VideauOrianne

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The CIME combination, a cocktail of ten drugs, showed good safety and accurate pharmacokinetic profiles in healthy volunteers, demonstrating its potential as a phenotyping tool.
Paper Details　
Original Abstract of the Article :
This phase I, pilot clinical study was designed to evaluate the safety and the pharmacokinetic (PK) profiles of the CIME (Metabolic Identity Card) combination of ten drugs, with a view to its use as a phenotyping cocktail. Ten healthy Caucasian subjects were orally dosed with the CIME combination (c...See full text at original site
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引用元：
https://doi.org/10.1007/s13318-014-0239-0

データ提供：米国国立医学図書館（NLM）

CIME Cocktail: A New Way to Assess Drug Metabolism

The field of drug metabolism is a complex and fascinating one, akin to navigating a vast and intricate desert landscape. This study, conducted in healthy volunteers, sought to develop a new and efficient method for assessing drug metabolism, the CIME cocktail, a combination of ten different drugs designed to provide a comprehensive picture of metabolic pathways. The authors utilized a phase I, pilot clinical trial to evaluate the safety and pharmacokinetic profiles of this unique cocktail. They found that CIME was well-tolerated and provided valuable information on the individual's metabolic capacity.

A Promising Tool for Personalized Medicine

This research has far-reaching implications for the future of personalized medicine. The CIME cocktail offers a powerful tool for tailoring drug therapy to individual patients based on their unique metabolic profile. This approach could potentially lead to more effective and safer drug treatment.

Optimizing Drug Therapy

Understanding how our bodies metabolize medications is crucial for optimizing drug therapy. This study provides valuable insights into the potential benefits of using personalized metabolic profiles to guide drug selection and dosage. It encourages a more individualized approach to healthcare, one that takes into account the unique characteristics of each patient.

Dr.Camel's Conclusion

The CIME cocktail is a promising tool for navigating the complex terrain of drug metabolism. It may be the key to unlocking a new era of personalized medicine, tailored to the specific needs of each individual.

Date :
  1. Date Completed 2016-12-14
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

25465228

DOI: Digital Object Identifier

10.1007/s13318-014-0239-0

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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