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Brain histamine H1 receptor occupancy measured by PET after oral administration of levocetirizine, a non-sedating antihistamine.

Author: GroboschThomas, HiraokaKotaro, IshiiKenji, IshiwataKiichi, MaurerMarcus, OdaKeiichi, TashiroManabu, ToyoharaJun, YanaiKazuhiko

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Levocetirizine, a second-generation antihistamine, showed less brain H1R occupancy and subjective sleepiness compared to fexofenadine, suggesting a better non-sedating profile.
Paper Details　
Original Abstract of the Article :
Histamine H1 receptor (H1R) antagonists often have sedative side effects, which are caused by the blockade of the neural transmission of the histaminergic neurons. We examined the brain H1R occupancy (H1RO) and the subjective sleepiness of levocetirizine, a new second-generation antihistamine, compa...See full text at original site
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引用元：
https://doi.org/10.1517/14740338.2015.989831

データ提供：米国国立医学図書館（NLM）

Levocetirizine: A Non-Sedating Antihistamine with Brain H1 Receptor Occupancy

This study examines the [brain H1 receptor occupancy (H1RO)] of [levocetirizine], a [non-sedating antihistamine], using [positron emission tomography (PET)]. The authors compared [levocetirizine] to [fexofenadine], another [non-sedating antihistamine], to assess the relationship between [H1RO] and [subjective sleepiness]. The results showed that [levocetirizine] achieved significant [H1RO] without causing [clinically significant sleepiness].

Navigating the Desert of Antihistamines: Finding the Right Oasis

This research sheds light on the [pharmacological profile] of [levocetirizine], demonstrating its ability to [block histamine receptors] in the brain without inducing [sedation]. This is like finding a hidden oasis in the desert of antihistamines - a source of relief that doesn't leave you feeling drowsy or sluggish. This study provides valuable information for clinicians when choosing [antihistamines] for patients.

A Clear Pathway to Relief: Avoiding the Drowsy Dunes

This research suggests that [levocetirizine] may be a good choice for [patients seeking allergy relief] without the unwanted side effect of [drowsiness]. This is like finding a clear pathway through a desert landscape, avoiding the treacherous dunes of sedation. This study provides valuable insights for [clinicians] and [patients] looking for a safe and effective [antihistamine] option.

Dr.Camel's Conclusion

This study provides a valuable perspective on the [pharmacological properties] of [levocetirizine], revealing its potential as a [non-sedating antihistamine]. It highlights the importance of understanding the [mechanisms of action] of medications and choosing the right options for individual patients. This research is a testament to the ongoing quest for new and effective medications that alleviate suffering without unwanted side effects.

Date :
  1. Date Completed 2015-09-14
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

25466429

DOI: Digital Object Identifier

10.1517/14740338.2015.989831

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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