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Antiproliferative and proapoptotic effects of topotecan in combination with thymoquinone on acute myelogenous leukemia.

Author: El-HayekStephany, HodrojMohammad Hassan, KhalifeRana, RizkSandra, StephanyEl-Hayek, TarrasOmayr

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This project studied the mode of action of topotecan along with thymoquinone, on survival and apoptosis pathways in acute myelogenous leukemia (AML) cell lines, and investigated the potential synergistic effect of thymoquinone on topotecan.
Paper Details　
Original Abstract of the Article :
Topotecan has shown promising antineoplastic activity in solid tumors and acute leukemia. Because of the primary dose-limiting toxicity of topotecan, it is necessary to identify other agents that can work synergistically with topotecan, potentially increasing its efficacy while limiting its toxicity...See full text at original site
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引用元：
https://doi.org/10.1016/j.clml.2014.04.014

データ提供：米国国立医学図書館（NLM）

Topotecan and Thymoquinone: A Collaborative Effort Against Leukemia

Acute myelogenous leukemia (AML) is a formidable foe, but researchers are constantly searching for new ways to combat it. This study focuses on the potential of combining two drugs, topotecan and thymoquinone, to effectively target AML cells. By combining these drugs, researchers aim to harness their individual strengths and create a synergistic effect against this type of cancer.

Synergistic Action Against AML

The study revealed that topotecan and thymoquinone can work together to effectively induce cell death in AML cells. This combination showed promise in inhibiting the growth and proliferation of these cancer cells, providing a potential avenue for more effective treatment.

Hope for More Effective AML Treatments

This research holds promise for the development of new and improved treatments for AML. By exploring combinations of existing drugs like topotecan and thymoquinone, researchers can potentially increase treatment effectiveness while minimizing side effects. This research is a promising step in the battle against AML.

Dr.Camel's Conclusion

This research is like a refreshing spring in the arid landscape of leukemia research. By exploring the synergistic effects of different drugs, researchers are paving the way for more effective and targeted treatments. This research offers hope for patients battling AML and provides a roadmap for future research in this critical field.

Date :
  1. Date Completed 2015-08-17
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

25486955

DOI: Digital Object Identifier

10.1016/j.clml.2014.04.014

Related Literature

Article Analysis
・Effects of topotecan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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