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The medical treatment of Parkinson disease from James Parkinson to George Cotzias.

Author: FahnStanley

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
BiographyA list of literature cited or referenced in a research paper or book. It shows the materials on which the research is based and is used to support the reliability of the paper.
Historical ArticleA research paper that analyzes past events and developments using primary sources and examines them from a historical perspective.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This abstract describes the history of Parkinson's disease (PD) treatment, highlighting the long journey from the disease's initial description to the development of effective therapies. It emphasizes the key role of levodopa, a dopamine precursor, in treating PD, and the critical contributions of researchers like Arvid Carlsson and Oleh Hornykiewicz in understanding the role of dopamine in PD. The abstract also discusses the challenges faced in early research, including limited efficacy and significant side effects, before the breakthrough achieved by George Cotzias with high-dosage levodopa therapy.
Paper Details　
Original Abstract of the Article :
It took exactly 150 years since James Parkinson's description in 1817 of the illness bearing his name until the development of effective therapy for this disorder, namely, the introduction of high-dosage levodopa by George Cotzias in 1967. During the first 50 years, no effective therapy was availabl...See full text at original site
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引用元：
https://doi.org/10.1002/mds.26102

データ提供：米国国立医学図書館（NLM）

The Evolution of Parkinson's Disease Treatment

The history of Parkinson's disease (PD) treatment is a testament to the tireless pursuit of effective therapies. From James Parkinson's initial description in 1817 to the breakthrough discovery of levodopa by George Cotzias in 1967, the journey has been marked by both setbacks and triumphs.

This comprehensive review traces the historical evolution of PD treatment, highlighting the key milestones and scientific advancements that led to our current understanding of the disease and its management. It's like traversing the vast desert of time, uncovering the hidden treasures of medical knowledge.

The review highlights the significance of scientific breakthroughs in unraveling the mysteries of PD and developing effective therapies. From the early reliance on plant-derived alkaloids to the discovery of dopamine's role in the disease, each step forward represented a crucial leap in our understanding of this debilitating condition. It's like discovering a new oasis in the desert, offering hope and relief to those suffering from this challenging disease.

The Importance of Continuous Innovation in Medical Research

The journey of PD treatment is a testament to the relentless pursuit of knowledge and innovation in medical research. The discovery of levodopa marked a turning point, providing a much-needed treatment for PD patients. However, the quest for better therapies continues, fueled by the dedication of scientists and clinicians who strive to improve the lives of those affected by this condition. It's like exploring a vast, uncharted desert, driven by a thirst for knowledge and a desire to make a difference.

The Future of Parkinson's Disease Treatment

The future of PD treatment holds great promise with ongoing research in areas such as gene therapy, stem cell transplantation, and neuroprotective agents. These advancements offer hope for more effective therapies and even potential cures for PD. It's like a journey through the desert, where every step forward brings us closer to a brighter future for those affected by this challenging disease.

Dr. Camel's Conclusion

The story of PD treatment is a reminder of the remarkable progress made in medicine, thanks to the dedication of scientists and clinicians. While challenges remain, ongoing research continues to offer hope for better treatments and a brighter future for those living with PD. It's a reminder that just like the desert, where life finds a way to thrive, human ingenuity and perseverance can overcome even the most daunting challenges.

Date :
  1. Date Completed 2015-09-11
  2. Date Revised 2015-02-02
Further Info :

Pubmed ID

25491387

DOI: Digital Object Identifier

10.1002/mds.26102

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