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The role of an acute pasireotide suppression test in predicting response to treatment in patients with Cushing's disease: findings from a pilot study.

Author: ArnaldiG, BarbotM, BoscaroM, CeccatoF, MarcelliG, MichettiG, ScaroniC, TrementinoL, ZilioM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

This study evaluated the value of an acute pasireotide suppression test (PST) in predicting response to medium/long-term treatment in Cushing's disease.
Paper Details　
Original Abstract of the Article :
Pasireotide is a multireceptor-targeted somatostatin analog effective in the treatment of Cushing's disease (CD). We evaluate the value of an acute pasireotide suppression test (PST) in predicting response to medium/long-term treatment in CD. Nineteen patients with active CD were prospectively inves...See full text at original site
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引用元：
https://doi.org/10.1007/s12020-014-0499-0

データ提供：米国国立医学図書館（NLM）

Pasireotide Suppression Test: A Guidepost in the Desert of Cushing's Disease

[Cushing's disease] is a hormonal disorder that can be challenging to manage, like a traveler lost in a desert, struggling to find their way back to balance and health. This study explores the use of an [acute pasireotide suppression test (PST)] to predict the response to long-term treatment in patients with Cushing's disease. This research is like discovering a new star in the desert sky, offering a potential guide for navigating the complexities of this hormonal disorder.

A Guiding Star: Predicting Response to Pasireotide Treatment

The study found that [a fall >27% of late-night salivary cortisol (LNSC) during PST] was a strong predictor of a positive response to pasireotide treatment. This finding is like finding a reliable landmark in the desert, offering a more predictable path to recovery for patients with Cushing's disease. This research provides valuable information for healthcare professionals, allowing them to more accurately predict the effectiveness of pasireotide treatment and tailor treatment plans for individual patients.

Navigating the Desert of Hormonal Imbalance

This study highlights the importance of ongoing research and development in the field of endocrinology. It underscores the need for personalized treatment approaches and the value of predictive tests to optimize patient care. Like a camel seeking a safe and reliable path through a desert, healthcare professionals must stay vigilant in their pursuit of effective treatments and improved outcomes for patients with Cushing's disease.

Dr. Camel's Conclusion

This research offers a promising new tool for managing Cushing's disease. The acute pasireotide suppression test provides a valuable guidepost for healthcare professionals, helping them make more informed decisions and provide personalized care to their patients.

Date :
  1. Date Completed 2016-06-20
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

25500791

DOI: Digital Object Identifier

10.1007/s12020-014-0499-0

Related Literature

Article Analysis
・Effects of pasireotide injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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