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Effects of danshen ethanol extract on the pharmacokinetics of fexofenadine in healthy volunteers.

Author: HeMin, JiangJian, LiuSongcan, MiaoPing, QiuFurong, ShenShujiao, YeYujie, ZengJin, ZhuLeilei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effect of danshen ethanol extract on fexofenadine pharmacokinetics. Multidose administration of danshen ethanol extract increased the oral clearance of fexofenadine, potentially due to induction of intestinal P-glycoprotein.
Paper Details　
Original Abstract of the Article :
This study investigated the effect of multidose administration of danshen ethanol extract on fexofenadine pharmacokinetics in healthy volunteers. A sequential, open-label, two-period pharmacokinetic interaction design was used. 12 healthy male volunteers received a single oral dose of fexofenadine (...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235188/

データ提供：米国国立医学図書館（NLM）

Danshen and Fexofenadine: A Tale of Two Drugs

This study delves into the fascinating world of [pharmacokinetics], investigating how [danshen ethanol extract] affects the absorption, distribution, metabolism, and excretion of [fexofenadine] in healthy individuals. Think of it like a desert oasis, where different substances interact and influence each other's journeys. This research reveals how [danshen ethanol extract] can influence the [oral clearance] of [fexofenadine], impacting its effectiveness in our bodies.

Danshen's Impact on Fexofenadine: A Desert Oasis of Interaction

The authors have discovered that [danshen ethanol extract] can significantly increase the [oral clearance] of [fexofenadine], leading to a decrease in the drug's overall exposure. This is due to the induction of [intestinal P-glycoprotein], which acts like a desert guard, preventing [fexofenadine] from staying in our bodies for too long.

Navigating the Desert of Drug Interactions: A Guide for Healthcare Professionals

This study provides important insights for healthcare professionals, especially when prescribing [fexofenadine] alongside [danshen ethanol extract]. It's crucial to be aware of these interactions to ensure the optimal effectiveness of [fexofenadine] and avoid potential complications.

Dr.Camel's Conclusion

This research highlights the importance of understanding drug interactions to ensure the safe and effective use of medications. Danshen ethanol extract can significantly alter the pharmacokinetics of fexofenadine, suggesting the need for careful consideration in prescribing these two medications together.

Date :
  1. Date Completed 2014-12-24
  2. Date Revised 2020-09-29
Further Info :

Pubmed ID

25538791

DOI: Digital Object Identifier

PMC4235188

Related Literature

Article Analysis
・Effects of fexofenadine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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