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The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized crossover trial.

Author: Abdel-MohsenMohamed, AlbrightRebecca, CohenMichelle, DeeksSteven G, DunhamRichard M, GorelickRobert, HsuePriscilla Y, HuangYong, HuntPeter W, LieglerTeri, LifsonJeffrey, MartinJeffrey N, McCuneJoseph M, PiatakMichael, SomsoukMa, WuYuaner

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effect of mesalamine on persistent immune activation in HIV-infected individuals. Mesalamine did not significantly impact the immune activation associated with HIV infection.
Paper Details　
Original Abstract of the Article :
The anti-inflammatory agent, mesalamine (5-aminosalicylic acid) has been shown to decrease mucosal inflammation in ulcerative colitis. The effect of mesalamine in HIV-infected individuals, who exhibit abnormal mucosal immune activation and microbial translocation (MT), has not been established in a ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283685/

データ提供：米国国立医学図書館（NLM）

Mesalamine for HIV-Infected Individuals with Incomplete CD4+ T Cell Recovery

This study explores the use of mesalamine, an anti-inflammatory agent, in HIV-infected individuals with incomplete CD4+ T cell recovery. The researchers conducted a randomized crossover trial to assess the impact of mesalamine on immune activation in these individuals. The study provides valuable insights into the potential role of mesalamine in managing persistent immune activation in HIV infection.

Mesalamine: A Search for Relief

The study investigates the potential of mesalamine to reduce immune activation in HIV-infected individuals with incomplete CD4+ T cell recovery. It's like searching for a hidden oasis in the vast desert of HIV research, hoping to find a solution to persistent immune activation. While the study's findings did not show a significant impact of mesalamine on immune activation, it provides valuable data for future research.

Navigating the Desert of HIV Research

The study highlights the complexities of managing HIV infection, a condition that can be like a harsh desert environment, challenging the body's immune system. The study's findings, while not conclusive, provide valuable insights into the potential of mesalamine and contribute to the ongoing search for effective treatments for HIV infection.

Dr.Camel's Conclusion

This study is a journey through the desert of HIV research, exploring the potential of mesalamine as a treatment for persistent immune activation. While the study's findings are not definitive, they provide valuable data for future research and contribute to the ongoing search for effective solutions to manage this complex condition.

Date :
  1. Date Completed 2015-09-08
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

25545673

DOI: Digital Object Identifier

PMC4283685

Related Literature

Article Analysis
・Effects of mesalamine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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