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Evaluation of the safety, tolerability, and pharmacokinetics of a single bolus injection of daptomycin in healthy Japanese subjects.

Author: AokiIkuo, AsoMasako, IshikawaKensuke, WakanaAkira, YoshinariTomoko

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This phase I study evaluated the safety, tolerability, and pharmacokinetics of a single bolus injection of daptomycin in healthy Japanese subjects. The 6 mg/kg dose was generally well tolerated, and pharmacokinetic data suggest that multiple-dose bolus injections may be similarly well tolerated and offer a potential clinical benefit.
Paper Details　
Original Abstract of the Article :
This was a phase I double-blind, randomized, placebo-controlled, 2-period, single-dose, crossover study in healthy Japanese subjects to evaluate the safety, tolerability, and pharmacokinetics of a single bolus injection of daptomycin. Twenty healthy subjects were randomized; 16 received a single int...See full text at original site
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引用元：
https://doi.org/10.1016/j.jiac.2014.11.001

データ提供：米国国立医学図書館（NLM）

Daptomycin: A New Antibiotic for Japanese Patients

This research delves into the safety, tolerability, and pharmacokinetics of daptomycin in healthy Japanese subjects, exploring the potential of this antibiotic for treating infections in this population. It's like conducting a scientific expedition into a new desert, exploring the effects of a new drug on a specific group of people. The research aims to determine if daptomycin is safe and effective for Japanese patients, paving the way for its potential use in treating infections.

Addressing Safety and Efficacy

The study examines the safety, tolerability, and pharmacokinetic profile of daptomycin in Japanese subjects. It's like testing the waters of a new oasis, ensuring that they are safe and refreshing for the inhabitants. This research provides valuable insights into the drug's potential use in Japanese patients, ensuring that it is safe and effective for this population.

Expanding Treatment Options

This research highlights the importance of studying the effects of medications in different populations, ensuring that treatment options are safe and effective for all. It's a reminder that the desert of drug development is vast and diverse, requiring careful exploration and testing to ensure the best outcomes for all. This research provides valuable data for clinicians in Japan, expanding their treatment options for patients with bacterial infections.

Dr.Camel's Conclusion

This research is a testament to the ongoing efforts to develop new and effective therapies for treating infections. It's a reminder that the journey to better health is a continuous one, requiring careful consideration of individual needs and diverse populations. This research is a beacon of knowledge, guiding us towards a more inclusive and effective approach to treating infections worldwide.
Date :
  1. Date Completed 2015-10-29
  2. Date Revised 2015-02-09
Further Info :

Pubmed ID

25572140

DOI: Digital Object Identifier

10.1016/j.jiac.2014.11.001

Related Literature

Article Analysis
・Effects of daptomycin injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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