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Therapy of endocrine disease: response and toxicity of small-molecule tyrosine kinase inhibitors in patients with thyroid carcinoma: a systematic review and meta-analysis.

Author: CorssmitE P, DekkersO M, KapiteijnE, Klein HesselinkE N, LefrandtJ D, LinksT P, SteenvoordenD, van der Horst-SchriversA N A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review and meta-analysis compared the efficacy and toxicity of tyrosine kinase inhibitors (TKIs) in patients with differentiated thyroid carcinoma (DTC) and medullary thyroid carcinoma (MTC). The aim was to summarize the response and toxicity profiles of TKIs in these specific subtypes of thyroid cancer.
Paper Details　
Original Abstract of the Article :
Many tyrosine kinase inhibitors (TKIs) have been studied in patients with thyroid carcinoma (TC). However, the effect and toxicity of various TKIs in differentiated TC (DTC) and medullary TC (MTC) patients have not been directly compared. The aim of the present systematic review and meta-analysis wa...See full text at original site
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引用元：
https://doi.org/10.1530/EJE-14-0788

データ提供：米国国立医学図書館（NLM）

Tyrosine Kinase Inhibitors: A New Oasis in the Desert of Thyroid Cancer Treatment

This study explores the potential of tyrosine kinase inhibitors (TKIs) as a new oasis in the desert of thyroid cancer treatment. The research focuses on the effectiveness and safety of these medications in patients with differentiated and medullary thyroid carcinoma, two distinct types of this disease. The authors perform a comprehensive review and meta-analysis to assess the impact of TKIs on these specific cancer subtypes. This research provides valuable insights into the evolving landscape of thyroid cancer treatment, offering potential new strategies to combat this disease.

Mapping the Potential of Tyrosine Kinase Inhibitors

The research meticulously maps the potential of tyrosine kinase inhibitors (TKIs) in the treatment of thyroid cancer. Like a seasoned desert explorer, the authors carefully analyze the efficacy and safety of these medications in different subtypes of the disease, providing valuable insights into their potential role in combating this challenging foe. The findings suggest that TKIs may represent a new oasis in the desert of thyroid cancer treatment, offering hope for improved outcomes for patients.

Navigating the Desert of Thyroid Cancer

This study provides valuable insights into the potential benefits of tyrosine kinase inhibitors (TKIs) in the treatment of thyroid cancer. By understanding the efficacy and safety of these medications, clinicians can better navigate the challenging landscape of this disease, employing these powerful tools to provide the best possible care for their patients. The findings suggest that TKIs may represent a new oasis in the desert of thyroid cancer treatment, offering a ray of hope for improved outcomes.

Dr. Camel's Conclusion

This research offers a glimmer of hope in the desert of thyroid cancer treatment. The potential of tyrosine kinase inhibitors provides a new oasis for patients, offering the promise of improved outcomes and a brighter future. By carefully considering the individual needs of each patient, clinicians can navigate this challenging landscape and find the path to effective treatment strategies.

Date :
  1. Date Completed 2015-05-22
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

25572389

DOI: Digital Object Identifier

10.1530/EJE-14-0788

SNS
PICO Info
in preparation
Languages

English

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