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Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design.

Author: CookJack A, EllensHarma, FengBo, GaletinAleksandra, LeeCaroline A, O'ConnorMeeghan A, PaineMary F, PolliJoseph W, Ragueneau-MajlessiIsabelle, RitchieTasha K, TaubMitchell E, WareJoseph A, Zamek-GliszczynskiMaciej J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the challenges and proposes strategies for conducting clinical drug-drug interaction (DDI) studies that are mediated by breast cancer resistance protein (BCRP). BCRP is a transporter protein involved in drug absorption and excretion. The review recommends specific substrates (sulfasalazine, rosuvastatin) and inhibitors (curcumin, lapatinib) for clinical DDI studies and suggests study design considerations to assess the worst-case scenario.
Paper Details　
Original Abstract of the Article :
Breast cancer resistance protein (BCRP; ABCG2) limits intestinal absorption of low-permeability substrate drugs and mediates biliary excretion of drugs and metabolites. Based on clinical evidence of BCRP-mediated drug-drug interactions (DDIs) and the c.421C>A functional polymorphism affecting drug e...See full text at original site
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引用元：
https://doi.org/10.1124/dmd.114.062174

データ提供：米国国立医学図書館（NLM）

BCRP and Drug Interactions: Navigating the Desert of Pharmaceutical Complexity

The field of clinical pharmacokinetics is like a vast desert, filled with complex interactions between drugs and the body. This research explores the role of breast cancer resistance protein (BCRP), a transporter that can affect the absorption and excretion of drugs, in drug-drug interactions. It’s like understanding the intricate pathways of a desert ecosystem, where different elements interact in complex and often unpredictable ways.

The Importance of BCRP

The researchers highlight the importance of understanding BCRP-mediated drug-drug interactions (DDIs), emphasizing the need for preclinical and clinical evaluation to ensure drug safety and efficacy. It’s like navigating a desert with a map and a compass, carefully planning the route to avoid dangerous encounters and ensure a safe journey. They propose specific substrates and inhibitors for clinical DDI studies, providing a framework for investigating these interactions.

Navigating the Desert of DDIs

This research provides valuable guidance for navigating the complex landscape of drug interactions, emphasizing the importance of careful consideration of BCRP’s role in drug pharmacokinetics. It’s like finding a skilled guide in the desert, one who understands the intricacies of the terrain and can help you navigate safely. The researchers call for further research to validate the proposed study design and solidify our understanding of BCRP-mediated DDIs, ensuring patient safety and optimal drug therapy.

Dr.Camel's Conclusion

This research highlights the critical role of BCRP in drug interactions, emphasizing the importance of careful consideration and investigation. It’s like navigating a desert with a keen eye, recognizing the potential for hidden dangers and taking precautions to ensure a safe journey. The findings underscore the need for further research to refine our understanding of BCRP-mediated DDIs and ensure the safe and effective use of drugs.

Date :
  1. Date Completed 2015-12-17
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

25587128

DOI: Digital Object Identifier

10.1124/dmd.114.062174

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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