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Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial.

Author: , BenowitzNeal L, CinciripiniPaul, GeorgeTony P, HawkLarry W, HeitjanDaniel F, LermanCaryn, SchnollRobert A, SwanGary E, TyndaleRachel F, WileytoE Paul

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the predictive power of a genetically informed biomarker, the nicotine metabolite ratio (NMR), for response to nicotine patch or varenicline treatment for smoking cessation. The study aimed to identify biomarkers that can optimize treatment choice for individual smokers, potentially improving outcomes.
Paper Details　
Original Abstract of the Article :
Substantial variability exists in therapeutic response and adverse effects with pharmacotherapies for tobacco dependence. Biomarkers to optimise treatment choice for individual smokers might improve treatment outcomes. We tested whether a genetically informed biomarker of nicotine clearance, the nic...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/25588294

データ提供：米国国立医学図書館（NLM）

The Nicotine Metabolite Ratio: A Guide Through the Smoking Cessation Desert

The desert of tobacco dependence is a treacherous place, with many individuals struggling to break free from addiction. This study explores the potential of the nicotine metabolite ratio (NMR) as a genetically informed biomarker to predict response to nicotine patch or varenicline for smoking cessation.

A New Tool for Personalized Smoking Cessation

The researchers investigated the relationship between NMR and treatment response, hoping to find a personalized approach to smoking cessation. It's like discovering a hidden compass in the desert, a tool that can guide individuals towards successful treatment options. The study aims to identify biomarkers that can tailor treatment approaches based on individual genetic makeup.

The Need for Further Investigation

The study emphasizes the need for further research to validate the role of NMR in predicting smoking cessation success. It's like exploring a new path in the desert, gathering more data and evidence to confirm its potential benefits.

Dr. Camel's Conclusion

This study sheds light on the potential of NMR as a valuable tool in the fight against tobacco dependence. It's a reminder that personalized approaches are crucial in navigating the complex desert of addiction, and that further research can help us find new ways to guide individuals towards healthier choices.

Date :
  1. Date Completed 2016-02-04
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

25588294

DOI: Digital Object Identifier

NIHMS661969

Related Literature

Article Analysis
・Side Effects of varenicline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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