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Differential effects of oxycodone, hydrocodone, and morphine on the responses of D2/D3 dopamine receptors.

Author: BatesM L Shawn, EitanShoshana, EmeryMichael A, WellmanPaul J

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that different opioids differentially modulate the responses of D2-like dopamine receptors, suggesting varying risks to the dopamine reward system.
Paper Details　
Original Abstract of the Article :
Oxycodone and hydrocodone are opioids which are widely used for pain management and are also commonly misused and abused. The exposure to opioid analgesics has been associated with altered responses of D2-like dopamine receptors (D2DRs). Our recent results suggest that various opioids will different...See full text at original site
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引用元：
https://doi.org/10.1016/j.bbr.2015.01.023

データ提供：米国国立医学図書館（NLM）

Opioids and Dopamine Receptors: A Desert of Addiction

Opioids are powerful medications, but they can be like a desert mirage, offering temporary relief but leading to a dangerous path of addiction. This research delves into the complex relationship between opioids and dopamine receptors, exploring how different opioids might affect the brain's reward system. It's like studying the effects of different types of sand on the movement of desert dunes.

Different Paths: A Desert of Addiction

The researchers found that different opioids, like oxycodone, hydrocodone, and morphine, had distinct effects on dopamine receptors. This is like observing how different types of wind patterns shape the sand dunes in a desert.

Understanding Addiction: Navigating the Desert of Reward

This research highlights the importance of understanding the complex interplay between opioids and the brain's reward system. It's a reminder that different opioids can carry different risks for addiction, and that personalized treatment approaches are essential.

Dr. Camel's Conclusion

This study underscores the need for a deeper understanding of how opioids interact with the brain's reward system. It provides valuable insights into the potential risks associated with different opioids, emphasizing the importance of responsible prescribing and careful monitoring. It's a journey through the desert of addiction, reminding us of the importance of staying vigilant and making informed choices when it comes to pain management.

Date :
  1. Date Completed 2015-12-07
  2. Date Revised 2015-03-21
Further Info :

Pubmed ID

25617530

DOI: Digital Object Identifier

10.1016/j.bbr.2015.01.023

Related Literature

Article Analysis
・Effects of hydrocodone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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