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Effects of adjunctive zonisamide treatment on weight and body mass index in children with partial epilepsy.

Author: GiorgiL, LagaeL, MeshramC, PattenA

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Approximately one-third of children treated with zonisamide experienced ≥ 5% weight loss. Weight loss was most apparent in children with high baseline BMI values and did not appear to be associated with any consistent effects on growth and development.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Zonisamide has been associated with weight loss in children and adults. AIMS OF THE STUDY: To assess the effects of adjunctive zonisamide on weight and body mass index (BMI) in children with partial epilepsy. METHODS: A subanalysis was conducted of a Phase III trial and extension study...See full text at original site
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引用元：
https://doi.org/10.1111/ane.12373

データ提供：米国国立医学図書館（NLM）

Zonisamide: A Potential Weight Loss Agent in Children with Epilepsy

Zonisamide is a medication used to treat epilepsy, but it has been associated with weight loss in children and adults. This study investigates the effects of zonisamide on weight and body mass index (BMI) in children with partial epilepsy. It's like observing a group of young camels in the desert – understanding how zonisamide could potentially impact their growth and development.

Zonisamide: A Double-Edged Sword for Weight Management

The study found that a significant proportion of children treated with zonisamide experienced weight loss. While this might be a desirable outcome for some, it raises concerns about the potential impact on growth and development. It's like discovering a new type of desert plant that can both provide sustenance and potentially have unexpected side effects.

Navigating Weight Management in Children with Epilepsy

This study emphasizes the need for careful monitoring and management of weight in children treated with zonisamide. It's like keeping a close watch on a young camel caravan in the desert, ensuring their health and well-being as they navigate the challenges of their journey.

Dr.Camel's Conclusion

This study highlights the complex relationship between zonisamide treatment and weight management in children with epilepsy. It's like navigating a desert landscape with both opportunities and potential pitfalls. By understanding these nuances, we can work towards optimizing treatment outcomes and ensuring the overall health and development of children with epilepsy.

Date :
  1. Date Completed 2015-10-16
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25659828

DOI: Digital Object Identifier

10.1111/ane.12373

Related Literature

Article Analysis
・Effects of zonisamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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