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Clinical and virologic follow-up in perinatally HIV-1-infected children and adolescents in Madrid with triple-class antiretroviral drug-resistant viruses.

Author: , Fernandez-CookeE, HolguínÁ, Jiménez de OryS, José MelladoM, NavarroM, PrietoL, Rojas SánchezP, RojoP, Tomas RamosJ, de MulderM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the virologic and clinical outcomes of perinatally HIV-infected children and adolescents with triple-class drug-resistant mutations (TC-DRM). Despite the presence of resistance to all three major classes of antiretroviral drugs, some drugs, including newer protease inhibitors and nonnucleoside reverse transcriptase inhibitors, retained their effectiveness.
Paper Details　
Original Abstract of the Article :
Drug resistance mutations compromise the success of antiretroviral treatment in human immunodeficiency virus type 1 (HIV-1)-infected children. We report the virologic and clinical follow-up of the Madrid cohort of perinatally HIV-infected children and adolescents after the selection of triple-class ...See full text at original site
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引用元：
https://doi.org/10.1016/j.cmi.2015.02.003

データ提供：米国国立医学図書館（NLM）

Triple-Class Drug-Resistant HIV-1 in Perinatally Infected Children and Adolescents

The fight against HIV-1 continues, with researchers constantly seeking new approaches to combat the virus's adaptability. This study focuses on a particularly challenging aspect: the emergence of triple-class drug-resistant mutations (TC-DRM) in perinatally HIV-1-infected children and adolescents. The authors investigate the virologic and clinical outcomes of these patients, analyzing the evolution of the virus and its response to antiretroviral therapy.

This study presents a compelling picture of the challenges posed by TC-DRM in HIV-1-infected children and adolescents. The authors reveal that despite the presence of resistance to various drug classes, certain newer antiretroviral agents, such as darunavir and etravirine, retain their effectiveness. The study emphasizes the importance of individualized treatment strategies and continued research to combat the evolving nature of HIV-1.

Strategies for Combating Resistance

This study underscores the critical need for continued research to develop new antiretroviral therapies that can overcome evolving HIV-1 resistance. The findings suggest that a combination of new drugs and individualized treatment strategies could potentially improve outcomes for patients with TC-DRM.

A Continuous Journey of Research

This study serves as a reminder that the fight against HIV-1 requires a continuous commitment to research and development. It highlights the challenges posed by drug resistance and underscores the need for ongoing efforts to develop effective treatment strategies for all HIV-1-infected individuals, particularly vulnerable populations like children and adolescents.

Dr.Camel's Conclusion

Just as a desert oasis may offer respite to weary travelers, new antiretroviral drugs can provide hope for those struggling with HIV-1. This study reminds us that the journey towards effective HIV-1 treatment is an ongoing one, and continued research is essential to overcome the challenges posed by drug resistance.

Date :
  1. Date Completed 2016-08-02
  2. Date Revised 2015-06-16
Further Info :

Pubmed ID

25680310

DOI: Digital Object Identifier

10.1016/j.cmi.2015.02.003

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Languages

English

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