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The Effects of Cinacalcet in Older and Younger Patients on Hemodialysis: The Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial.

Author: , BlockGeoffrey A, ChertowGlenn M, Correa-RotterRicardo, DehmelBastian, DrüekeTilman B, FloegeJürgen, GoodmanWilliam G, HerzogCharles A, KuboYumi, LondonGerard M, MahaffeyKenneth W, MoeSharon M, ParfreyPatrick S, WheelerDavid C

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of the calcimimetic cinacalcet on the risk of death or cardiovascular (CV) events in patients with secondary hyperparathyroidism (HPT). Cinacalcet was found to reduce this risk in older patients, but not in younger patients, potentially due to differences in baseline CV risk and use of cointerventions.
Paper Details　
Original Abstract of the Article :
The calcimimetic cinacalcet reduced the risk of death or cardiovascular (CV) events in older, but not younger, patients with moderate to severe secondary hyperparathyroidism (HPT) who were receiving hemodialysis. To determine whether the lower risk in younger patients might be due to lower baseline ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422239/

データ提供：米国国立医学図書館（NLM）

The Effects of Cinacalcet in Older and Younger Patients on Hemodialysis: The EVOLVE Trial

This study takes us on a journey into the realm of [renal disease], specifically focusing on [secondary hyperparathyroidism (HPT)] in [hemodialysis patients]. The researchers conducted [a large-scale clinical trial] known as [EVOLVE] to investigate [the effects of cinacalcet, a calcimimetic agent], on [cardiovascular (CV) outcomes] in both [older and younger patients] with [moderate to severe HPT]. The study's aim was to determine [if cinacalcet's benefits were consistent across different age groups].

Cinacalcet's Effects on Cardiovascular Outcomes in Hemodialysis Patients

The study's findings revealed [a significant difference] in [the effectiveness of cinacalcet] between [older and younger patients] with [HPT]. While [cinacalcet] was found to [reduce the risk of death or CV events] in [older patients], it did not show [the same benefits] in [younger patients]. This discrepancy suggests that [cinacalcet's effectiveness] may be influenced by [age-related factors] and [the overall CV risk profile] of patients.

Implications for Hemodialysis Treatment

This study provides [valuable insights] into [the complexities of managing HPT] in [hemodialysis patients]. It emphasizes [the importance of considering age and CV risk] when [making treatment decisions] for [HPT]. The study's findings highlight [the need for tailored treatment approaches] based on [individual patient characteristics] to [optimize outcomes] and [minimize potential risks].

Dr.Camel's Conclusion

This study, like a camel traversing the vast desert of [renal disease research], has uncovered [a complex relationship between age and the effectiveness of cinacalcet] in [Hemodialysis patients]. The researchers' findings, like a hidden oasis in the desert, provide [crucial information] for [clinicians] who are treating [HPT] in [this patient population]. This research is a testament to the importance of [considering individual factors] when [making treatment decisions] and [striving for personalized approaches] to [improve patient care].
Date :
  1. Date Completed 2016-05-19
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25710802

DOI: Digital Object Identifier

PMC4422239

Related Literature

Article Analysis
・Effects of cinacalcet
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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