Paper Details

  1. Home
  2. Paper Details

A predictive in vitro model of the impact of drugs with anticholinergic properties on human neuronal and astrocytic systems.

Author: ColemanMichael D, FoxG Christopher, HillEric J, MaidmentIan D, ParriH Rheinallt, TseErin H Y, WoehrlingElizabeth K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Anticholinergic drugs can cause cognitive impairment in older adults. This study investigated the use of a new model to predict the anticholinergic effects of drugs. The model used a co-culture of human neurons and astrocytes. The study found that the model was able to accurately predict the anticholinergic effects of drugs.
Paper Details　
Original Abstract of the Article :
The link between off-target anticholinergic effects of medications and acute cognitive impairment in older adults requires urgent investigation. We aimed to determine whether a relevant in vitro model may aid the identification of anticholinergic responses to drugs and the prediction of anticholiner...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349811/

データ提供：米国国立医学図書館（NLM）

Anticholinergic Drugs and Brain Cells: A Delicate Balance

Anticholinergic drugs are widely used to treat various conditions, but they can have unintended consequences, particularly in older adults. This study explores the potential impact of these drugs on brain cells, using a model that replicates the complex interaction between neurons and astrocytes. It's like a desert ecosystem where different types of plants and animals coexist, and the delicate balance can be disrupted by an invasive species.

Predicting Anticholinergic Risk: A New Tool for Researchers

This study presents a promising new tool for understanding how anticholinergic drugs affect brain cells. This type of research is crucial for identifying and preventing potential cognitive problems associated with these medications, especially in vulnerable populations like the elderly.

Understanding Anticholinergics: A Must for Older Adults

This study emphasizes the importance of carefully considering the potential risks and benefits of anticholinergic drugs, particularly in older adults who are more susceptible to cognitive decline. It highlights the importance of open communication with healthcare professionals and taking a proactive approach to managing medications.

Dr.Camel's Conclusion

Just as a camel's delicate balance in the desert can be disrupted by unforeseen changes, anticholinergic drugs can have a subtle impact on the delicate balance of our brain cells. This study sheds light on the importance of understanding these potential risks and making informed decisions about our medications.

Date :
  1. Date Completed 2016-01-19
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

25738989

DOI: Digital Object Identifier

PMC4349811

Related Literature

Article Analysis
・Effects of dicyclomine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.