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Antimicrobial efficacy of doripenem and its combinations with sulbactam, amikacin, colistin, tigecycline in experimental sepsis of carbapenem-resistant Acinetobacter baumannii.

Author: AhmedSalman Shaheer, AlpEmine, DemiraslanHayati, DincGokcen, DoganayMehmet, ElmaliFerhan

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Acinetobacter baumannii is a type of bacteria that is becoming increasingly resistant to antibiotics. This study investigated the effectiveness of different antibiotic combinations in treating A. baumannii infections. The study found that combination therapy with doripenem and either tigecycline or amikacin was more effective than monotherapy with doripenem.
Paper Details　
Original Abstract of the Article :
Acinetobacter baumannii is the most common species to have developed resistance to antibiotics. Due to increasing levels of drug resistance, the available therapeutic options are insufficient in A. baumannii infections. This study investigated the efficacy of doripenem monotherapy versus doripenem c...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/25742149

データ提供：米国国立医学図書館（NLM）

Combating Drug-Resistant Acinetobacter baumannii: A New Approach

This research ventures into the battleground of antimicrobial resistance, focusing on the formidable foe: Acinetobacter baumannii. This bacterium has become a major concern due to its ability to develop resistance to antibiotics. The study investigated the efficacy of doripenem, a carbapenem antibiotic, both alone and in combination with other antibiotics, in treating experimental sepsis caused by carbapenem-resistant A. baumannii. The researchers found that doripenem combinations with sulbactam, amikacin, colistin, and tigecycline were more effective than monotherapy in reducing bacterial load, highlighting the potential for combination therapies to combat drug resistance.

Fighting Resistance: The Power of Combination Therapies

This research underscores the importance of combination therapies in combating drug-resistant bacteria. The study demonstrates that combining doripenem with other antibiotics significantly enhanced its effectiveness in treating sepsis caused by carbapenem-resistant A. baumannii. These findings encourage further exploration of combination therapies as a promising approach to tackle antibiotic resistance.

Antibiotic Resistance: A Growing Threat

The emergence of drug-resistant bacteria poses a significant threat to public health. This study highlights the urgent need for innovative strategies, such as combination therapies, to combat antimicrobial resistance and ensure effective treatment options for infectious diseases.

Dr.Camel's Conclusion

The study provides valuable insights into the efficacy of doripenem combinations in combating carbapenem-resistant A. baumannii. The findings are encouraging and suggest that combination therapies hold promise as a weapon against drug-resistant infections. This research underscores the critical need for ongoing efforts to develop new antibiotics and strategies to overcome the growing challenge of antimicrobial resistance.

Date :
  1. Date Completed 2015-05-08
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25742149

DOI: Digital Object Identifier

25742149

Related Literature

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・Effects of doripenem injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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