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Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy.

Author: KitamuraShigeyuki, OhtaShigeru, SanohSeigo, SugiharaKazumi, TayamaYoshitaka

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Aldehyde oxidase is an enzyme that plays an important role in drug metabolism. It can affect how quickly a drug is broken down in the body and how long it stays in the system. Aldehyde oxidase can also affect the side effects of a drug. While the enzyme is important, it can be unstable, making it difficult to study in the lab. However, scientists are using animal models and human biomarkers to learn more about the role of aldehyde oxidase in drug metabolism.
Paper Details　
Original Abstract of the Article :
Aldehyde oxidase contributes to drug metabolism and pharmacokinetics (PK), and a few clinical studies were discontinued because of aldehyde oxidase metabolism. Its AOX1, AOX3, AOX3L1, and AOX4 isoforms are expressed in mammals, and species differences in expression profiles reflect differences in dr...See full text at original site
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引用元：
https://doi.org/10.1016/j.dmpk.2014.10.009

データ提供：米国国立医学図書館（NLM）

Aldehyde Oxidase: A Key Player in Drug Metabolism

This study explores the role of aldehyde oxidase, an enzyme that plays a crucial role in drug metabolism, in drug development. Think of it as exploring a hidden oasis in the desert of biochemistry, where a special enzyme helps break down and process various substances. This research investigates the importance of understanding aldehyde oxidase activity when developing new medications.

The study highlights the significance of aldehyde oxidase in drug metabolism, pharmacokinetics, toxicity, and efficacy. It emphasizes the importance of considering species differences and individual variations in aldehyde oxidase activity when designing new drugs. It's like understanding the diverse landscape of a desert, where different plants and animals react differently to the environment.

The Importance of Personalized Medicine

This study underscores the importance of personalized medicine, where treatments are tailored to the individual patient's needs. It's a reminder that the desert of the human body is vast and complex, and each individual may respond differently to medications. This research emphasizes the need to consider individual variations in enzyme activity when developing new treatments.

Implications for Drug Development

This research provides valuable insights for drug developers, highlighting the importance of understanding the role of enzymes like aldehyde oxidase in drug metabolism. It's like studying the intricate workings of a desert ecosystem, where each element plays a crucial role in the overall balance. This knowledge can help to create safer and more effective medications for patients.

Dr. Camel's Conclusion

This study reminds us that the journey towards developing safe and effective medications is a complex one. It's like navigating a vast and intricate desert, where each element of the ecosystem plays a crucial role. By understanding the role of enzymes like aldehyde oxidase, we can create new drugs that are tailored to the specific needs of each patient.

Date :
  1. Date Completed 2016-03-21
  2. Date Revised 2015-03-12
Further Info :

Pubmed ID

25760530

DOI: Digital Object Identifier

10.1016/j.dmpk.2014.10.009

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