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Pharmacodynamic interactions of a solid formulation of sodium oxybate and ethanol in healthy volunteers.

Author: BidautMichelle, FauchouxNicolas, PatatAlain, ProssNathalie, VivetPhilippe

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Sodium oxybate (SO) and alcohol have distinct adverse effect profiles. The objective effects of SMO.IR were much less marked than those of alcohol. No deleterious interaction was observed.
Paper Details　
Original Abstract of the Article :
AIM: The pharmacologic effects of sodium oxybate (SO) have a number of similarities with those of alcohol. This study evaluated the pharmacodynamic interaction of SMO.IR (a solid immediate release formulation of SO) and alcohol (0.7 (males) or 0.57 (females) g kg(-1) alcohol using 40% vodka). METHO...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574833/

データ提供：米国国立医学図書館（NLM）

Mixing Sodium Oxybate and Ethanol: A Look at Pharmacodynamic Interactions

In the realm of [pharmacology], understanding the interactions between medications is crucial for patient safety. This research focuses on the potential interactions between [sodium oxybate (SO)] and [ethanol (alcohol)], both of which can have similar effects on the central nervous system. The researchers investigated the pharmacodynamic interactions between these two substances in healthy volunteers.

The study found that [SO] and [ethanol] do have distinct profiles, with [SO] producing less pronounced cognitive impairment and subjective sedation compared to [ethanol]. While co-administration led to some mild interactions, the combination was generally well-tolerated. This research provides valuable insights into the potential risks and benefits of co-administering [SO] and [ethanol].

A Balanced Approach: Sodium Oxybate and Ethanol Interactions

This research highlights the importance of understanding the pharmacodynamic interactions between [sodium oxybate (SO)] and [ethanol (alcohol)]. While the two substances can have similar effects, the study found distinct profiles and some potential for mild interactions. These findings underscore the importance of careful consideration when co-administering these substances.

Informed Decision-Making: Considering Sodium Oxybate and Ethanol

This research provides valuable information for healthcare professionals and patients regarding the potential interactions between [SO] and [ethanol]. The study's findings emphasize the importance of informed decision-making regarding the co-administration of these substances, ensuring patient safety and well-being.

Dr. Camel's Conclusion

This research explores the pharmacodynamic interactions between [sodium oxybate (SO)] and [ethanol (alcohol)], two substances with similar effects on the central nervous system. The study found that while both substances can have similar effects, their profiles differ, and co-administration can lead to some mild interactions. This research underscores the importance of careful consideration and informed decision-making regarding the co-administration of these substances.

Date :
  1. Date Completed 2016-06-03
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

25782469

DOI: Digital Object Identifier

PMC4574833

SNS
PICO Info
in preparation
Languages

English

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